Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ciclesonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 11/20 | 1.00 |
| ▸ | PGR | P06401 | 7/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 1.00 |
| ▸ | CNR1 | P21554 | 1/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.59 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.59 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.59 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.59 |
| ▸ | IL5 | P05113 | 1/20 | 0.59 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.59 |
| ▸ | AR | P10275 | 1/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.59 |
| ▸ | MMP9 | P14780 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | THPO | P40225 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ciclesonide SCHEMBL15830978 | 1.00 | NR3C1 (1.00) | NR3C1PGRNR1I2ADORA3CNR1 | |
| Ciclesonide SCHEMBL3688 | 1.00 | NR3C1 (1.00) | NR3C1PGRNR1I2ADORA3CNR1 | |
| Ciclesonide SCHEMBL4782166 | 1.00 | NR3C1 (1.00) | NR3C1PGRNR1I2ADORA3CNR1 | |
| Ciclesonide SCHEMBL14493775 | 1.00 | NR3C1 (1.00) | NR3C1PGRNR1I2ADORA3CNR1 | |
| Ciclesonide SCHEMBL1244607 | 1.00 | NR3C1 (1.00) | NR3C1PGRNR1I2ADORA3CNR1 | |
| Ciclesonide SCHEMBL13575757 | 1.00 | NR3C1 (1.00) | NR3C1PGRNR1I2ADORA3CNR1 | |
| Ciclesonide SCHEMBL17439183 | 1.00 | NR3C1 (1.00) | NR3C1PGRNR1I2ADORA3CNR1 | |
| Ciclesonide SCHEMBL13014882 | 1.00 | NR3C1 (1.00) | NR3C1PGRNR1I2ADORA3CNR1 | |
| Ciclesonide SCHEMBL5700709 | 1.00 | NR3C1 (1.00) | NR3C1PGRNR1I2ADORA3CNR1 | |
| Ciclesonide SCHEMBL139353 | 1.00 | NR3C1 (1.00) | NR3C1PGRNR1I2ADORA3CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230310634-A1 | ANTI-HUMAN VISTA ANTIBODIES AND USE THEREOF | IMMUNEXT INC (US) | 2023-10-05 | — | — | US | disclosed |
| US-20230310634-A1 | ANTI-HUMAN VISTA ANTIBODIES AND USE THEREOF | IMMUNEXT INC (US) | 2023-10-05 | — | — | US | disclosed |
| WO-2021216913-A1 | ANTI-HUMAN VISTA ANTIBODIES AND USE THEREOF | IMMUNEXT, INC. (US) | 2021-10-28 | — | — | WO | disclosed |
| US-11007150-B2 | Pharmaceutical aerosol product for administration by oral or nasal inhalation | COVIS PHARMA GMBH (CH) | 2021-05-18 | — | — | US | disclosed |
| US-20200338208-A1 | GLUCOCORTICOID RECEPTOR AGONIST AND IMMUNOCONJUGATES THEREOF | ABBVIE INC. (US) | 2020-10-29 | — | — | US | disclosed |
| US-10668167-B2 | Glucocorticoid receptor agonist and immunoconjugates thereof | ABBVIE INC. (US) | 2020-06-02 | — | — | US | disclosed |
| US-20190262465-A1 | GLUCOCORTICOID RECEPTOR AGONIST AND IMMUNOCONJUGATES THEREOF | ABBVIE INC. (US) | 2019-08-29 | — | — | US | disclosed |
| US-20180126000-A1 | GLUCOCORTICOID RECEPTOR AGONIST AND IMMUNOCONJUGATES THEREOF | ABBVIE INC. (US) | 2018-05-10 | — | — | US | disclosed |
| US-20180126000-A1 | GLUCOCORTICOID RECEPTOR AGONIST AND IMMUNOCONJUGATES THEREOF | ABBVIE INC. (US) | 2018-05-10 | — | — | US | disclosed |
| WO-2017207776-A1 | SYSTEM FOR DISPENSING A COSMETIC PRODUCT | L'OREAL (FR) | 2017-12-07 | — | — | WO | disclosed |
| US-20100222572-A1 | PROCESSES FOR THE PREPARATION OF CICLESONIDE AND ITS CRYSTAL MODIFICATION | CIPLA LIMITED (IN) | 2010-09-02 | — | — | US | disclosed |
| US-20100222572-A1 | PROCESSES FOR THE PREPARATION OF CICLESONIDE AND ITS CRYSTAL MODIFICATION | CIPLA LIMITED (IN) | 2010-09-02 | — | — | US | disclosed |
| US-20090227548-A1 | Novel Glucocorticoid Receptor Agonists | GLOSSOP PAUL ALAN | 2009-09-10 | — | — | US | disclosed |
| US-20090227548-A1 | Novel Glucocorticoid Receptor Agonists | GLOSSOP PAUL ALAN | 2009-09-10 | — | — | US | disclosed |
| WO-2009069032-A2 | NOVEL GLUCOCORTICOID RECEPTOR AGONISTS | PFIZER LIMITED (GB) | 2009-06-04 | — | — | WO | disclosed |
| US-20070232578-A1 | Crystalline forms of ciclesonide | SICOR, INC. | 2007-10-04 | — | — | US | disclosed |
| US-20070232578-A1 | Crystalline forms of ciclesonide | SICOR, INC. | 2007-10-04 | — | — | US | disclosed |
| WO-2007092574-A2 | CRYSTALLINE FORMS OF CICLESONIDE | SICOR, INC. (US) | 2007-08-16 | — | — | WO | disclosed |
| US-20070135398-A1 | Process for the preparation of ciclesonide | SICOR, INC. | 2007-06-14 | — | — | US | disclosed |
| US-20070135398-A1 | Process for the preparation of ciclesonide | SICOR, INC. | 2007-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232578-A1 | Crystalline forms of ciclesonide | CRYZ, CRYAB, HSD3B2 | NR3C1 77/4885PGR 2083/4885NR1I2 324/4885 |
| US-11007150-B2 | Pharmaceutical aerosol product for administration by oral or nasal inhalation | IL5, TSLP, CFTR | NR3C1 2491/4885PGR 4755/4885NR1I2 2050/4885 |
| US-20180126000-A1 | GLUCOCORTICOID RECEPTOR AGONIST AND IMMUNOCONJUGATES THEREOF | NR3C1, NR3C2, MC2R | NR3C1 1/4885PGR 197/4885NR1I2 163/4885 |
| US-20200338208-A1 | GLUCOCORTICOID RECEPTOR AGONIST AND IMMUNOCONJUGATES THEREOF | NR3C1, NR3C2, MC2R | NR3C1 1/4885PGR 197/4885NR1I2 163/4885 |
| US-20090227548-A1 | Novel Glucocorticoid Receptor Agonists | NR3C1, NR3C2, MC2R | NR3C1 1/4885PGR 231/4885NR1I2 80/4885 |
| US-10668167-B2 | Glucocorticoid receptor agonist and immunoconjugates thereof | NR3C1, NR3C2, MC2R | NR3C1 1/4885PGR 197/4885NR1I2 163/4885 |
| US-20100222572-A1 | PROCESSES FOR THE PREPARATION OF CICLESONIDE AND ITS CRYSTAL MODIFICATION | CYP17A1, CYP4A11, NR5A1 | NR3C1 17/4885PGR 221/4885NR1I2 200/4885 |
| US-20070135398-A1 | Process for the preparation of ciclesonide | IL23R, CYP4A22, IL17A | NR3C1 44/4885PGR 586/4885NR1I2 417/4885 |
| US-20230310634-A1 | ANTI-HUMAN VISTA ANTIBODIES AND USE THEREOF | CD47, CLTA, FCGR2A | NR3C1 104/4885PGR 2891/4885NR1I2 1668/4885 |
| US-20190262465-A1 | GLUCOCORTICOID RECEPTOR AGONIST AND IMMUNOCONJUGATES THEREOF | NR3C1, NR3C2, MC2R | NR3C1 1/4885PGR 197/4885NR1I2 163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.