Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAA50 | Q9GZZ1 | 11/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 4/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20705068 | 1.00 | NAA50 (0.42) | NAA50KLKB1JAK2JAK1KMT2A | |
| SCHEMBL20713767 | 0.83 | KLKB1 (0.47) | NAA50KLKB1KMT2AL3MBTL1 | |
| SCHEMBL20713722 | 0.82 | KLKB1 (0.53) | NAA50KLKB1 | |
| SCHEMBL20705172 | 0.82 | KLKB1 (0.53) | NAA50KLKB1 | |
| SCHEMBL20705151 | 0.81 | KLKB1 (0.45) | NAA50KLKB1 | |
| SCHEMBL20705179 | 0.80 | KLKB1 (0.45) | KLKB1 | |
| SCHEMBL20713811 | 0.76 | TRPC3 (0.43) | KLKB1 | |
| SCHEMBL20713814 | 0.76 | TRPC3 (0.43) | KLKB1 | |
| SCHEMBL10077029 | 0.75 | NAA50 (0.43) | NAA50NR1H2NR1H3 | |
| SCHEMBL20705122 | 0.74 | CASP3 (0.39) | NAA50KLKB1KMT2ANR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3661922-A1 | INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF | Dyax Corp. (US) | 2020-06-10 | — | — | EP | disclosed |
| WO-2019028362-A1 | INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF | DYAX CORP. (US) | 2019-02-07 | — | — | WO | disclosed |