SCHEMBL20705293

SCHEMBL20705293

C[C@H](O)C(=O)c1ccc(F)c(C(F)(F)F)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC8 Q9BY41 1/20 0.50
TAS1R3 Q7RTX0 2/20 0.48
TAS1R1 Q7RTX1 2/20 0.48
TAS1R2 Q8TE23 2/20 0.48
CHRNA1 P02708 1/20 0.45
CHRNG P07510 1/20 0.45
CHRNB1 P11230 1/20 0.45
CHRNB2 P17787 1/20 0.45
SLC6A2 P23975 1/20 0.45
CHRNB4 P30926 1/20 0.45
CHRNA3 P32297 1/20 0.45
CHRNA4 P43681 1/20 0.45
SLC6A3 Q01959 1/20 0.45
CHRND Q07001 1/20 0.45
AR P10275 2/20 0.43
KIF11 P52732 1/20 0.43
KCNQ3 O43525 1/20 0.43
KCNQ2 O43526 1/20 0.43
KCNE1 P15382 1/20 0.43
KCNQ1 P51787 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20705294 1.00 HDAC8 (0.50) HDAC8TAS1R3TAS1R1TAS1R2CHRNA1
SCHEMBL20363926 0.88 HDAC8 (0.54) HDAC8TAS1R3TAS1R1TAS1R2CHRNA1
SCHEMBL12780344 0.88 HDAC8 (0.54) HDAC8TAS1R3TAS1R1TAS1R2CHRNA1
SCHEMBL311225 0.85 HDAC8 (0.49) HDAC8TAS1R3TAS1R1TAS1R2CHRNA1
SCHEMBL20702565 0.82 KDR (0.51) HDAC8SLC6A3GRM4
SCHEMBL20702566 0.82 KDR (0.51) HDAC8SLC6A3GRM4
SCHEMBL5307700 0.81 KCNQ3 (0.47) HDAC8TAS1R3TAS1R1TAS1R2CHRNA1
SCHEMBL6955765 0.80 CES2 (0.62) TAS1R3TAS1R1TAS1R2CHRNA1CHRNG
SCHEMBL22288575 0.80 CHRNA1 (0.50) HDAC8TAS1R3TAS1R1TAS1R2CHRNA1
SCHEMBL22288577 0.80 CHRNA1 (0.50) HDAC8TAS1R3TAS1R1TAS1R2CHRNA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12258323-B2 Dihydrooxadiazinones BAYER AKTIENGESELLSCHAFT (DE) 2025-03-25 US disclosed
CN-111212647-B Dihydro oxadiazinones 拜耳股份有限公司 2024-05-14 CN disclosed
US-11773070-B2 Dihydrooxadiazinones BAYER AKTIENGESELLSCHAFT (DE) 2023-10-03 US disclosed
US-11773070-B2 Dihydrooxadiazinones BAYER AKTIENGESELLSCHAFT (DE) 2023-10-03 US disclosed
US-11773070-B2 Dihydrooxadiazinones BAYER AKTIENGESELLSCHAFT (DE) 2023-10-03 US disclosed
EP-3661517-B1 DIHYDROOXADIAZINONES BAYER AG (DE) 2023-09-13 EP disclosed
EP-3661517-B1 DIHYDROOXADIAZINONES BAYER AG (DE) 2023-09-13 EP disclosed
US-20230017200-A1 DIHYDROOXADIAZINONES BAYER AKTIENGESELLSCHAFT (DE) 2023-01-19 US disclosed
US-20230017200-A1 DIHYDROOXADIAZINONES BAYER AKTIENGESELLSCHAFT (DE) 2023-01-19 US disclosed
US-20220396554-A1 DIHYDROOXADIAZINONES BAYER AKTIENGESELLSCHAFT (DE) 2022-12-15 US disclosed
US-20220396554-A1 DIHYDROOXADIAZINONES BAYER AKTIENGESELLSCHAFT (DE) 2022-12-15 US disclosed
US-11427553-B2 Dihydrooxadiazinones BAYER AKTIENGESELLSCHAFT (DE) 2022-08-30 US disclosed
US-20200369633-A1 DIHYDROOXADIAZINONES BAYER AKTIENGESELLSCHAFT (DE) 2020-11-26 US disclosed
US-20200369633-A1 DIHYDROOXADIAZINONES BAYER AKTIENGESELLSCHAFT (DE) 2020-11-26 US disclosed
WO-2020157188-A1 DIHYDROOXADIAZINONES FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES BAYER AKTIENGESELLSCHAFT (DE) 2020-08-06 WO disclosed
WO-2020157188-A1 DIHYDROOXADIAZINONES FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES BAYER AKTIENGESELLSCHAFT (DE) 2020-08-06 WO disclosed
EP-3661517-A1 DIHYDROOXADIAZINONES Bayer Aktiengesellschaft (DE) 2020-06-10 EP disclosed
CN-111212647-A Dihydroxadiazinones 拜耳股份有限公司 2020-05-29 CN disclosed
WO-2019025562-A1 DIHYDROOXADIAZINONES BAYER AKTIENGESELLSCHAFT (DE) 2019-02-07 WO disclosed
WO-2019025562-A1 DIHYDROOXADIAZINONES BAYER AKTIENGESELLSCHAFT (DE) 2019-02-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200369633-A1 DIHYDROOXADIAZINONES CCND2, CCNT2, CCND1 HDAC8 2458/4885TAS1R3 4633/4885TAS1R1 4443/4885
US-11773070-B2 Dihydrooxadiazinones CCND2, DPYD, DHPS HDAC8 2476/4885TAS1R3 4623/4885TAS1R1 4447/4885
US-20220396554-A1 DIHYDROOXADIAZINONES CCND2, DPYD, DHPS HDAC8 2476/4885TAS1R3 4623/4885TAS1R1 4447/4885
US-12258323-B2 Dihydrooxadiazinones CCND2, CCNT2, CCND1 HDAC8 2458/4885TAS1R3 4633/4885TAS1R1 4443/4885
US-20230017200-A1 DIHYDROOXADIAZINONES CCND2, CCNT2, CCND1 HDAC8 2458/4885TAS1R3 4633/4885TAS1R1 4443/4885
US-11427553-B2 Dihydrooxadiazinones CCND2, CCNT2, CCND1 HDAC8 2458/4885TAS1R3 4633/4885TAS1R1 4443/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.