SCHEMBL20705366

SCHEMBL20705366

Cc1cc(Nc2cccc(-c3cc(C)c(-c4cccc(Nc5ccc(-c6ccccc6)c(C)c5)c4)cc3C)c2)ccc1-c1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR2 Q92731 1/20 0.47
NPSR1 Q6W5P4 1/20 0.46
ALDH1A1 P00352 4/20 0.44
MEN1 O00255 2/20 0.44
MAPT P10636 2/20 0.44
KMT2A Q03164 2/20 0.44
AR P10275 1/20 0.44
CNR1 P21554 1/20 0.43
HPGD P15428 2/20 0.41
APP P05067 1/20 0.41
CYP17A1 P05093 1/20 0.40
SLC1A3 P43003 1/20 0.39
SLC1A2 P43004 1/20 0.39
SLC1A1 P43005 1/20 0.39
NR1H4 Q96RI1 1/20 0.39
TSHR P16473 2/20 0.39
HSD17B10 Q99714 2/20 0.39
TDP1 Q9NUW8 2/20 0.39
L3MBTL1 Q9Y468 2/20 0.39
ALOX15 P16050 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20705367 0.90 ESR2 (0.50) ESR2NPSR1ALDH1A1MEN1MAPT
SCHEMBL20705368 0.88 ESR2 (0.52) ESR2NPSR1ALDH1A1MEN1MAPT
SCHEMBL22356061 0.80 CNR1 (0.55) NPSR1ALDH1A1MEN1MAPTKMT2A
SCHEMBL4639004 0.80 HPGD (0.58) NPSR1ALDH1A1MEN1MAPTKMT2A
SCHEMBL29416259 0.80 HPGD (0.58) NPSR1ALDH1A1MEN1MAPTKMT2A
SCHEMBL13308526 0.80 HPGD (0.58) NPSR1ALDH1A1MEN1MAPTKMT2A
SCHEMBL14825186 0.79 RARB (0.41) ESR2NPSR1SLC1A3SLC1A2SLC1A1
SCHEMBL4423918 0.79 ESR2 (0.46) ESR2NPSR1ALDH1A1MEN1MAPT
SCHEMBL23609407 0.79 SLC1A3 (0.52) ESR2NPSR1ALDH1A1MEN1MAPT
SCHEMBL130523 0.78 CNR1 (0.54) NPSR1ALDH1A1MEN1MAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10199577-B2 Electroactive materials E I DU PONT DE NEMOURS AND COMPANY (US) 2019-02-05 US disclosed