Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 16/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 16/20 | 0.47 |
| ▸ | POLB | P06746 | 11/20 | 0.47 |
| ▸ | MAPT | P10636 | 8/20 | 0.47 |
| ▸ | RECQL | P46063 | 5/20 | 0.44 |
| ▸ | THRB | P10828 | 3/20 | 0.44 |
| ▸ | BLM | P54132 | 2/20 | 0.44 |
| ▸ | NSD2 | O96028 | 2/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.43 |
| ▸ | MMP2 | P08253 | 2/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13464887 | 0.65 | KMT2A (0.55) | MEN1KMT2APOLBMAPTTHRB | |
| SCHEMBL22523765 | 0.55 | SNRNP200 (0.88) | MEN1KMT2APOLBMAPTRECQL | |
| SCHEMBL12924181 | 0.44 | SMN1; SMN2 (0.35) | MEN1KMT2APOLBMAPTKDM4E | |
| SCHEMBL13172821 | 0.41 | ALDH1A1 (0.38) | ALDH1A1 | |
| Biphenyl SCHEMBL28074752 | 0.41 | ALDH1A1 (0.57) | KMT2APOLBTDP1ALDH1A1 | |
| SCHEMBL5314209 | 0.41 | ALDH1A1 (0.57) | KMT2APOLBTDP1ALDH1A1 | |
| SCHEMBL10315999 | 0.41 | L3MBTL3 (0.58) | ALDH1A1L3MBTL1MAPK1CYP3A4CYP2C9 | |
| SCHEMBL26777511 | 0.41 | KMT2A (0.44) | MEN1KMT2APOLBMAPTKDM4E | |
| SCHEMBL31058208 | 0.40 | USP2 (0.41) | POLBKDM4EALDH1A1HPGDCYP1A2 | |
| SCHEMBL22938022 | 0.40 | ALDH1A1 (0.53) | KMT2APOLBTDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10195213-B2 | Chemical entities that kill senescent cells for use in treating age-related disease | UNITY BIOTECHNOLOGY, INC. (US) | 2019-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10195213-B2 | Chemical entities that kill senescent cells for use in treating age-related disease | TP53, CDKN1A, GLA | MEN1 2434/4885KMT2A 2501/4885POLB 417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.