⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9524067 | 0.87 | — | — | |
| SCHEMBL13659733 | 0.72 | — | — | |
| SCHEMBL1543389 | 0.71 | CYP1A2 (0.32) | — | |
| SCHEMBL15337522 | 0.69 | — | — | |
| Ethylene SCHEMBL28641046 | 0.68 | CYP1A2 (0.31) | — | |
| SCHEMBL321303 | 0.68 | LMNA (0.32) | — | |
| SCHEMBL10339691 | 0.67 | — | — | |
| SCHEMBL28952671 | 0.65 | — | — | |
| SCHEMBL28635931 | 0.64 | — | — | |
| SCHEMBL5924204 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0267432-B1 | ANTIBACTERIALLY ACTIVE PYRIDO-BENZOTHIAZINE DERIVATIVES WITH LONG TERM ACTION | MEDIOLANUM FARMACEUTICI s.r.l. (IT) | 1991-12-27 | — | — | EP | claimed |
| US-4868299-A | Antibacterially active pyrido-benzothiazine derivatives with long-term action | MEDIOLANUM FARMACEUTICI SRL (IT) | 1989-09-19 | — | — | US | claimed |
| EP-0267432-A1 | Antibacterially active pyrido-benzothiazine derivatives with long term action | MEDIOLANUM FARMACEUTICI s.r.l. (IT) | 1988-05-18 | — | — | EP | claimed |
| EP-2522670-A1 | Heterocyclic CRF receptor antagonists | Takeda Pharmaceutical Company Limited (JP) | 2012-11-14 | — | — | EP | disclosed |
| US-7897607-B2 | Cyclic compounds | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-03-01 | — | — | US | disclosed |
| EP-1732541-A4 | CYCLIC COMPOUNDS | TAKEDA PHARMACEUTICAL (JP) | 2008-03-05 | — | — | EP | disclosed |
| US-20070179165-A1 | Cyclic compounds | GYORKOS ALBERT C | 2007-08-02 | — | — | US | disclosed |
| WO-2007026215-A1 | PYRAZOLE DERIVATIVES AS CANNABINOID RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS CONTAINING? THEM, AND PROCESSES FOR THEIR PREPARATION | GLENMARK PHARMACEUTICALS S.A. (US) | 2007-03-08 | — | — | WO | disclosed |
| EP-1732541-A2 | CYCLIC COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005099688-A2 | CYCLIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-10-27 | — | — | WO | disclosed |
| EP-1419155-A2 | PIPERIDINE DERIVATIVES AS ANTIBACTERIAL AGENTS | SMITHKLINE BEECHAM PLC (GB) | 2004-05-19 | — | — | EP | disclosed |
| WO-2003010138-A2 | PIPERIDINE DERIVATIVES AS ANTIBACTERIAL AGENTS | SMITHKLINE BEECHAM PLC (GB) | 2003-02-06 | — | — | WO | disclosed |
| US-6465653-B2 | HEATING AND HYDROLYZING/DECARBOXYLATING 4-HYDROXYQUINOLINE CARBOXYLIC ACID ESTER IN PRESENCE OF WATER IN LIQUID OR VAPOR PHASE; PLANT SAFENING AGENTS | RHODIA CHIMIE (FR) | 2002-10-15 | — | — | US | disclosed |
| US-20020007067-A1 | Noncatalyzed synthesis of 4-hydroxyquinolines and/or tautomers thereof | RHODIA CHIMIE (FR) | 2002-01-17 | — | — | US | disclosed |
| WO-1996040138-A1 | CHLOROQUINE ANALOGS AND METHODS OF PREVENTING AND TREATING PLASMODIAL DISEASE | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (US) | 1996-12-19 | — | — | WO | disclosed |
| US-4868299-A | Antibacterially active pyrido-benzothiazine derivatives with long-term action | MEDIOLANUM FARMACEUTICI SRL (IT) | 1989-09-19 | — | — | US | disclosed |
| US-4450166-A | N-(4,5-Dihydro-thiazol-2-yl)-3-quinoline-carboxamides having anxiolytic activity | ROUSSEL UCLAF (FR) | 1984-05-22 | — | — | US | disclosed |
| US-4277607-A | Process for the preparation of 4-chloroquinolines | ROUSSEL UCLAF (FR) | 1981-07-07 | — | — | US | disclosed |
| US-4250178-A | NEUROLEPTIC AGENTS | DELALANDE S.A. (FR) | 1981-02-10 | — | — | US | disclosed |
| US-4190661-A | BACTERICIDES | LABORATOIRES CHAUVIN-BLACHE (FR) | 1980-02-26 | — | — | US | disclosed |