Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 6/20 | 0.53 |
| ▸ | KDR | P35968 | 4/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | RIPK3 | Q9Y572 | 5/20 | 0.46 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.39 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16820015 | 0.78 | KDR (0.42) | RIPK1KDRBRAFRIPK3GAA | |
| SCHEMBL16845374 | 0.78 | KDR (0.42) | RIPK1KDRBRAFRIPK3GAA | |
| SCHEMBL31417701 | 0.77 | NPC1 (0.47) | KDRBRAFGAAMEN1KMT2A | |
| SCHEMBL31417741 | 0.77 | EPHX2 (0.47) | KDRBRAFGAAKMT2AEPHX2 | |
| SCHEMBL27352139 | 0.77 | EPHX2 (0.47) | KDRBRAFGAAKMT2AEPHX2 | |
| SCHEMBL20707879 | 0.76 | KDR (0.41) | RIPK1KDRBRAFRIPK3GAA | |
| SCHEMBL31135377 | 0.74 | BRAF (0.47) | KDRBRAFGAAEPHX2FFAR4 | |
| SCHEMBL18919031 | 0.73 | CA2 (0.43) | KDRBRAF | |
| SCHEMBL16845423 | 0.73 | CA2 (0.43) | KDRBRAF | |
| SCHEMBL1984984 | 0.73 | SMN1; SMN2 (0.49) | KDRBRAFTSHRFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2888229-B1 | alpha7 NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS AND USES THEREOF | MERCK SHARP & DOHME (US) | 2019-02-06 | — | — | EP | disclosed |