Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 18/20 | 0.80 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.77 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.77 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.77 |
| ▸ | MMP12 | P39900 | 1/20 | 0.77 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20708412 | 1.00 | ADAMTS5 (0.80) | ADAMTS5ADAM17ADAMTS4ADAM10MMP12 | |
| SCHEMBL22892253 | 0.90 | ADAMTS5 (0.75) | ADAMTS5ADAM17ADAMTS4ADAM10MMP12 | |
| SCHEMBL24533767 | 0.89 | ADAMTS5 (0.64) | ADAMTS5ADAM17ADAMTS4ADAM10MMP12 | |
| SCHEMBL20708541 | 0.87 | ADAMTS5 (1.00) | ADAMTS5ADAM17ADAMTS4ADAM10MMP12 | |
| SCHEMBL20708345 | 0.86 | ADAMTS5 (0.65) | ADAMTS5ADAM17ADAMTS4ADAM10MMP12 | |
| SCHEMBL20708577 | 0.85 | ADAMTS5 (0.78) | ADAMTS5ADAM17ADAMTS4ADAM10MMP12 | |
| SCHEMBL19691581 | 0.85 | ADAMTS5 (0.77) | ADAMTS5ADAM17ADAMTS4ADAM10MMP12 | |
| SCHEMBL21582804 | 0.83 | ADAMTS5 (0.73) | ADAMTS5ADAM17ADAMTS4ADAM10MMP12 | |
| SCHEMBL22892377 | 0.82 | ADAMTS5 (0.73) | ADAMTS5ADAM17ADAMTS4ADAM10MMP12 | |
| SCHEMBL19691696 | 0.82 | ADAMTS5 (0.73) | ADAMTS5ADAM17ADAMTS4ADAM10MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3237406-B1 | 5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | GALAPAGOS NV (BE) | 2019-02-06 | — | — | EP | disclosed |