Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 18/20 | 0.78 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.72 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.72 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.72 |
| ▸ | MMP12 | P39900 | 1/20 | 0.72 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.72 |
| ▸ | MMP2 | P08253 | 1/20 | 0.58 |
| ▸ | MMP13 | P45452 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.51 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.51 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.51 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20708337 | 0.85 | ADAMTS5 (0.80) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL20708412 | 0.85 | ADAMTS5 (0.80) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL20708333 | 0.85 | ADAMTS5 (1.00) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL20708392 | 0.85 | ADAMTS5 (1.00) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL20708541 | 0.84 | ADAMTS5 (1.00) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL20708262 | 0.82 | ADAMTS5 (0.83) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL22892377 | 0.82 | ADAMTS5 (0.73) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL19691696 | 0.82 | ADAMTS5 (0.73) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL19691629 | 0.82 | ADAMTS5 (0.67) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL21403972 | 0.82 | ADAMTS5 (0.67) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3237406-B1 | 5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | GALAPAGOS NV (BE) | 2019-02-06 | — | — | EP | disclosed |