Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 19/20 | 0.75 |
| ▸ | MMP2 | P08253 | 5/20 | 0.75 |
| ▸ | MMP13 | P45452 | 3/20 | 0.72 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.72 |
| ▸ | ADAMTS1 | Q9UHI8 | 1/20 | 0.72 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.71 |
| ▸ | MMP1 | P03956 | 1/20 | 0.68 |
| ▸ | MMP12 | P39900 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20708335 | 0.87 | MMP2 (0.67) | ADAMTS5MMP2MMP13ADAMTS4ADAMTS1 | |
| SCHEMBL20708380 | 0.87 | ADAMTS5 (0.74) | ADAMTS5MMP2MMP13ADAMTS4ADAMTS1 | |
| SCHEMBL17871423 | 0.86 | ADAMTS5 (1.00) | ADAMTS5MMP2MMP13ADAMTS4ADAM17 | |
| SCHEMBL20708573 | 0.86 | ADAMTS5 (0.75) | ADAMTS5MMP2MMP13ADAMTS4ADAMTS1 | |
| SCHEMBL17871397 | 0.83 | ADAMTS5 (1.00) | ADAMTS5MMP2MMP13ADAMTS4ADAMTS1 | |
| SCHEMBL20708267 | 0.83 | MMP2 (0.70) | ADAMTS5MMP2MMP13ADAMTS4ADAMTS1 | |
| SCHEMBL17871227 | 0.83 | ADAMTS5 (1.00) | ADAMTS5MMP2MMP13ADAMTS4ADAMTS1 | |
| SCHEMBL17871350 | 0.83 | ADAMTS5 (1.00) | ADAMTS5MMP2MMP13ADAMTS4ADAMTS1 | |
| SCHEMBL20708292 | 0.83 | MMP2 (0.75) | ADAMTS5MMP2MMP13ADAMTS4ADAMTS1 | |
| SCHEMBL20708252 | 0.82 | ADAMTS5 (0.82) | ADAMTS5MMP2MMP13ADAMTS4ADAMTS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3575294-A1 | 5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | Les Laboratoires Servier (FR) | 2019-12-04 | — | — | EP | disclosed |
| EP-3237406-B1 | 5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | GALAPAGOS NV (BE) | 2019-02-06 | — | — | EP | disclosed |