Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 8/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.72 |
| ▸ | MEN1 | O00255 | 6/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.72 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.72 |
| ▸ | TSHR | P16473 | 6/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.72 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.72 |
| ▸ | LMNA | P02545 | 5/20 | 0.72 |
| ▸ | PDE5A | O76074 | 4/20 | 0.72 |
| ▸ | USP2 | O75604 | 4/20 | 0.72 |
| ▸ | TP53 | P04637 | 2/20 | 0.72 |
| ▸ | GBA1 | P04062 | 2/20 | 0.72 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.72 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.72 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.72 |
| ▸ | POLB | P06746 | 2/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7276945 | 0.86 | CYP1A2 (0.80) | CYP1A2CYP3A4CYP2D6MEN1KMT2A | |
| SCHEMBL15289677 | 0.85 | TSHR (0.77) | CYP1A2CYP3A4CYP2D6MEN1KMT2A | |
| SCHEMBL7286130 | 0.85 | PDE5A (1.00) | CYP1A2CYP3A4CYP2D6MEN1KMT2A | |
| SCHEMBL7432190 | 0.82 | MAPT (0.74) | CYP1A2CYP3A4CYP2D6MEN1KMT2A | |
| SCHEMBL7277274 | 0.81 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2D6MEN1KMT2A | |
| SCHEMBL7280049 | 0.81 | ALDH1A1 (0.80) | CYP1A2CYP3A4CYP2D6MEN1KMT2A | |
| SCHEMBL7280346 | 0.81 | KMT2A (0.82) | CYP1A2CYP3A4CYP2D6MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL7287894 | 0.81 | ALDH1A1 (0.79) | CYP1A2CYP3A4CYP2D6MEN1KMT2A | |
| SCHEMBL7279569 | 0.81 | PDE5A (0.77) | CYP1A2CYP3A4CYP2D6MEN1KMT2A | |
| SCHEMBL7411431 | 0.80 | PDE5A (0.71) | CYP1A2CYP3A4CYP2D6MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200283444-A1 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS AND USES THEREOF | NORTHWESTERN UNIVERSITY | 2020-09-10 | — | — | US | disclosed |
| WO-2019027765-A1 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS AND USES THERE | NORTHWESTERN UNIVERSITY (US) | 2019-02-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200283444-A1 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS AND USES THEREOF | GBA3, GBA1, GBA2 | CYP1A2 4410/4885CYP3A4 4190/4885CYP2D6 2479/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.