Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 13/20 | 0.47 |
| ▸ | NPC1 | O15118 | 12/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | GFER | P55789 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | PKM | P14618 | 3/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14452085 | 0.74 | NPC1 (0.55) | RAB9ANPC1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL171008 | 0.74 | PTGS1 (0.52) | PTGS1PTGS2RAB9ANPC1KDM4E | |
| SCHEMBL423547 | 0.73 | NPC1 (0.58) | RAB9ANPC1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6395294 | 0.73 | APP (0.67) | RAB9ANPC1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL31731985 | 0.73 | RAB9A (0.67) | PTGS1PTGS2RAB9ANPC1KDM4E | |
| SCHEMBL3313092 | 0.71 | RAB9A (0.65) | PTGS1PTGS2RAB9ANPC1KDM4E | |
| SCHEMBL2079932 | 0.71 | PTGS1 (0.58) | PTGS1PTGS2RAB9ANPC1KDM4E | |
| SCHEMBL1876442 | 0.71 | PTGS1 (0.53) | PTGS1PTGS2RAB9ANPC1KDM4E | |
| SCHEMBL16231147 | 0.70 | TLR9 (0.48) | RAB9ANPC1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1876349 | 0.70 | PTGS1 (0.51) | PTGS1PTGS2RAB9ANPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019028362-A1 | INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF | DYAX CORP. (US) | 2019-02-07 | — | — | WO | disclosed |