Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.72 |
| ▸ | MAPT | P10636 | 2/20 | 0.72 |
| ▸ | APAF1 | O14727 | 1/20 | 0.72 |
| ▸ | RECQL | P46063 | 1/20 | 0.72 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.72 |
| ▸ | MMP9 | P14780 | 9/20 | 0.67 |
| ▸ | MMP8 | P22894 | 8/20 | 0.67 |
| ▸ | MMP1 | P03956 | 5/20 | 0.67 |
| ▸ | MMP3 | P08254 | 5/20 | 0.67 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12358201 | 0.87 | MAPT (0.70) | POLBKDM4EMAPTAPAF1RECQL | |
| SCHEMBL7854107 | 0.87 | KDM4E (0.70) | POLBKDM4EMAPTAPAF1RECQL | |
| SCHEMBL12358205 | 0.87 | MAPT (0.70) | POLBKDM4EMAPTAPAF1RECQL | |
| SCHEMBL22277253 | 0.86 | KDM4E (0.60) | POLBKDM4EMAPTAPAF1RECQL | |
| SCHEMBL17017538 | 0.86 | POLB (0.69) | POLBKDM4EMAPTAPAF1RECQL | |
| SCHEMBL7678071 | 0.85 | KDM4E (0.67) | POLBKDM4EMAPTAPAF1RECQL | |
| SCHEMBL19687957 | 0.85 | KDM4E (0.67) | POLBKDM4EMAPTAPAF1RECQL | |
| SCHEMBL6577399 | 0.84 | MMP9 (0.66) | POLBKDM4EMAPTAPAF1RECQL | |
| SCHEMBL631048 | 0.84 | KDM4E (0.70) | POLBKDM4EMAPTAPAF1RECQL | |
| SCHEMBL29850214 | 0.84 | KDM4E (0.70) | POLBKDM4EMAPTAPAF1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019028362-A1 | INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF | DYAX CORP. (US) | 2019-02-07 | — | — | WO | disclosed |