Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | APAF1 | O14727 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | MMP9 | P14780 | 7/20 | 0.58 |
| ▸ | MMP8 | P22894 | 7/20 | 0.58 |
| ▸ | MMP1 | P03956 | 3/20 | 0.58 |
| ▸ | MMP3 | P08254 | 2/20 | 0.58 |
| ▸ | ECE1 | P42892 | 2/20 | 0.57 |
| ▸ | MMP2 | P08253 | 7/20 | 0.57 |
| ▸ | ACE | P12821 | 2/20 | 0.56 |
| ▸ | CTSC | P53634 | 1/20 | 0.56 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | HTR1D | P28221 | 1/20 | 0.55 |
| ▸ | HTR1B | P28222 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20713624 | 0.86 | POLB (0.72) | KDM4EAPAF1POLBMAPTRECQL | |
| SCHEMBL14565344 | 0.85 | KDM4E (0.74) | KDM4EAPAF1POLBMAPTRECQL | |
| SCHEMBL22600369 | 0.84 | KDM4E (0.60) | KDM4EAPAF1POLBMAPTRECQL | |
| SCHEMBL12868909 | 0.84 | KDM4E (0.60) | KDM4EAPAF1POLBMAPTRECQL | |
| SCHEMBL25766157 | 0.83 | KDM4E (0.63) | KDM4EAPAF1POLBMAPTRECQL | |
| SCHEMBL631048 | 0.82 | KDM4E (0.70) | KDM4EAPAF1POLBMAPTRECQL | |
| SCHEMBL6577399 | 0.82 | MMP9 (0.66) | KDM4EAPAF1POLBMAPTRECQL | |
| SCHEMBL29850214 | 0.82 | KDM4E (0.70) | KDM4EAPAF1POLBMAPTRECQL | |
| SCHEMBL16182036 | 0.82 | MMP9 (0.66) | KDM4EAPAF1POLBMAPTRECQL | |
| SCHEMBL876693 | 0.82 | KDM4E (0.70) | KDM4EAPAF1POLBMAPTRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11168083-B2 | Inhibitors of Plasma Kallikrein and uses thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2021-11-09 | — | — | US | disclosed |
| US-20200239463-A1 | INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF | DYAX CORP. (US) | 2020-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11168083-B2 | Inhibitors of Plasma Kallikrein and uses thereof | KLKB1, KLK1, KLK5 | KDM4E 1766/4885APAF1 498/4885POLB 3451/4885 |
| US-20200239463-A1 | INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF | KLKB1, KLK1, KLK5 | KDM4E 1766/4885APAF1 498/4885POLB 3451/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.