Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18319382 | 0.83 | MAPT (0.64) | EGFRMAPTKDM4EHTTLMNA | |
| SCHEMBL17807848 | 0.83 | EGFR (0.52) | EGFRMAPTKDM4ESMN1; SMN2HTT | |
| SCHEMBL7853508 | 0.83 | MAPT (0.58) | EGFRMAPTKDM4ESMN1; SMN2HTT | |
| SCHEMBL28946156 | 0.81 | MAPT (0.50) | EGFRMAPTKDM4ESMN1; SMN2HTT | |
| SCHEMBL28946188 | 0.81 | EGFR (0.48) | EGFRMAPTKDM4ESMN1; SMN2HTT | |
| SCHEMBL13964060 | 0.80 | PGK1 (0.50) | MAPTLMNAALDH1A1MAPK1CYP3A4 | |
| SCHEMBL13407309 | 0.78 | MAPT (0.59) | EGFRMAPTKDM4ESMN1; SMN2HTT | |
| SCHEMBL10810171 | 0.78 | GSK3B (0.58) | MAPTSMN1; SMN2HTTLMNAMEN1 | |
| SCHEMBL17807850 | 0.77 | CYP1A2 (0.53) | EGFRMAPTKDM4ESMN1; SMN2HTT | |
| SCHEMBL7099122 | 0.77 | EGFR (0.55) | EGFRMAPTKDM4ESMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019028308-A1 | BENZIMIDAZOLES AND AZA-BENZIMIDAZOLES, AND METHODS OF USE THEREOF | GOLDFINCH BIO, INC. (US) | 2019-02-07 | — | — | WO | disclosed |