Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.58 |
| ▸ | EGFR | P00533 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18319382 | 0.86 | MAPT (0.64) | MAPTEGFRHTTLMNAMAPK1 | |
| SCHEMBL20715310 | 0.83 | EGFR (0.52) | MAPTEGFRHTTLMNAMAPK1 | |
| SCHEMBL17807848 | 0.83 | EGFR (0.52) | MAPTEGFRHTTLMNAMAPK1 | |
| SCHEMBL6087097 | 0.81 | SIRT5 (0.54) | MAPTEGFRHTTLMNAMAPK1 | |
| SCHEMBL7843791 | 0.80 | SIRT5 (0.45) | MAPTEGFRHTTLMNAMAPK1 | |
| SCHEMBL27993407 | 0.79 | PGK1 (0.49) | MAPTHTTLMNAMAPK1ALDH1A1 | |
| SCHEMBL28946188 | 0.79 | EGFR (0.48) | MAPTEGFRHTTLMNAMAPK1 | |
| SCHEMBL28946156 | 0.79 | MAPT (0.50) | MAPTEGFRHTTLMNAMAPK1 | |
| SCHEMBL5759562 | 0.77 | POLB (0.55) | MAPTEGFRHTTLMNAMAPK1 | |
| SCHEMBL31631301 | 0.77 | NPC1 (0.74) | MAPTEGFRHTTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087963-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | Chiron Corporation (US) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065897-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 1999-12-23 | — | — | WO | disclosed |