Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.33 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.30 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.30 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4983910 | 1.00 | PDE10A (0.33) | PDE10AKCNQ3KCNQ2PDE1B | |
| SCHEMBL22360169 | 0.83 | TLR7 (0.32) | PDE10A | |
| SCHEMBL22360139 | 0.83 | TLR7 (0.32) | PDE10A | |
| SCHEMBL24368979 | 0.80 | PIK3CD (0.37) | PDE10A | |
| SCHEMBL24820178 | 0.80 | PIK3CD (0.37) | PDE10A | |
| SCHEMBL23374669 | 0.80 | PIK3CD (0.37) | PDE10A | |
| SCHEMBL4326980 | 0.77 | PDE10A (0.31) | PDE10A | |
| SCHEMBL23975685 | 0.74 | ESR1 (0.37) | PDE10AKCNQ3KCNQ2PDE1B | |
| SCHEMBL14207964 | 0.74 | ESR1 (0.37) | PDE10AKCNQ3KCNQ2PDE1B | |
| SCHEMBL20340914 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7863281-B2 | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2011-01-04 | — | — | US | disclosed |
| US-20080103161-A1 | BICYCLIC HETEROCYCLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESSES FOR THE PREPARATION THEREOF | HIMMELSBACH FRANK | 2008-05-01 | — | — | US | disclosed |
| US-20050159436-A1 | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2005-07-21 | — | — | US | disclosed |
| EP-1499619-A1 | BICYCLIC HETEROCYCLES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE, AND METHOD FOR THE PRODUCTION THEREOF | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2005-01-26 | — | — | EP | disclosed |
| US-20040044014-A1 | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-03-04 | — | — | US | disclosed |
| WO-2003089439-A1 | BICYCLIC HETEROCYCLES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE, AND METHOD FOR THE PRODUCTION THEREOF | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2003-10-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050159436-A1 | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof | RET, CYP11B1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | PDE10A 302/4885KCNQ3 3101/4885KCNQ2 2980/4885 |
| US-20040044014-A1 | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof | CYP11B1, CYP11B2, AR | PDE10A 526/4885KCNQ3 3404/4885KCNQ2 3415/4885 |
| US-20080103161-A1 | BICYCLIC HETEROCYCLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESSES FOR THE PREPARATION THEREOF | RET, CYP11B1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | PDE10A 302/4885KCNQ3 3101/4885KCNQ2 2980/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.