Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.59 |
| ▸ | MAPT | P10636 | 7/20 | 0.59 |
| ▸ | HPGD | P15428 | 7/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.59 |
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8238275 | 0.81 | ALDH1A1 (0.57) | ALDH1A1MAPTHPGDHSD17B10TP53 | |
| SCHEMBL26968212 | 0.78 | HSD17B10 (0.54) | ALDH1A1MAPTHPGDHSD17B10TP53 | |
| SCHEMBL4420424 | 0.75 | MAPT (0.56) | ALDH1A1MAPTHPGDHSD17B10TP53 | |
| SCHEMBL8153543 | 0.74 | HSD17B10 (0.63) | ALDH1A1MAPTHPGDHSD17B10TP53 | |
| SCHEMBL18496514 | 0.73 | ALDH1A1 (0.48) | ALDH1A1MAPTHPGDHSD17B10TP53 | |
| SCHEMBL25575139 | 0.72 | MAPT (0.75) | ALDH1A1MAPTHPGDHSD17B10TP53 | |
| SCHEMBL3338630 | 0.71 | HSD17B10 (0.46) | ALDH1A1MAPTHPGDHSD17B10TP53 | |
| SCHEMBL846222 | 0.70 | ALDH1A1 (0.41) | ALDH1A1HPGDHSD17B10KDM4EL3MBTL1 | |
| SCHEMBL8144828 | 0.69 | HSD17B10 (0.66) | ALDH1A1MAPTHPGDHSD17B10TP53 | |
| SCHEMBL11544945 | 0.68 | HSD17B10 (0.64) | ALDH1A1MAPTHPGDHSD17B10TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7863444-B2 | 4-aminopyrrolopyrimidines as kinase inhibitors | ABBOTT LABORATORIES (US) | 2011-01-04 | — | — | US | disclosed |