Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 9/20 | 0.61 |
| ▸ | CDK5 | Q00535 | 8/20 | 0.61 |
| ▸ | CDK5R1 | Q15078 | 8/20 | 0.61 |
| ▸ | CHEK1 | O14757 | 8/20 | 0.61 |
| ▸ | CCNB2 | O95067 | 7/20 | 0.61 |
| ▸ | CDK1 | P06493 | 7/20 | 0.61 |
| ▸ | CCNB1 | P14635 | 7/20 | 0.61 |
| ▸ | CCNB3 | Q8WWL7 | 7/20 | 0.61 |
| ▸ | RAF1 | P04049 | 4/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.61 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.61 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.61 |
| ▸ | PRKCG | P05129 | 3/20 | 0.61 |
| ▸ | PRKCB | P05771 | 3/20 | 0.61 |
| ▸ | PRKCA | P17252 | 3/20 | 0.61 |
| ▸ | PRKCH | P24723 | 3/20 | 0.61 |
| ▸ | PRKCI | P41743 | 3/20 | 0.61 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.61 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.61 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hymenialdisine SCHEMBL1249687 | 0.90 | CHEK2 (0.74) | CHEK2CDK5CDK5R1CHEK1CCNB2 | |
| Hymenialdisine SCHEMBL155899 | 0.90 | CHEK2 (0.74) | CHEK2CDK5CDK5R1CHEK1CCNB2 | |
| Hymenialdisine SCHEMBL1249686 | 0.90 | CHEK2 (0.74) | CHEK2CDK5CDK5R1CHEK1CCNB2 | |
| Hymenialdisine SCHEMBL6031276 | 0.87 | CDK5 (0.69) | CHEK2CDK5CDK5R1CHEK1CCNB2 | |
| Hymenialdisine SCHEMBL18114524 | 0.76 | CDK5 (1.00) | CHEK2CDK5CDK5R1CHEK1CCNB2 | |
| Hymenialdisine SCHEMBL15426167 | 0.76 | CDK5 (1.00) | CHEK2CDK5CDK5R1CHEK1CCNB2 | |
| Spongiacidin D SCHEMBL15426068 | 0.72 | CDK5 (1.00) | CHEK2CDK5CDK5R1CHEK1CCNB2 | |
| Hymenialdisine SCHEMBL24393900 | 0.70 | CDK5 (0.76) | CHEK2CDK5CDK5R1CHEK1CCNB2 | |
| Debromohymenialdisine SCHEMBL3578000 | 0.70 | CDK5 (0.70) | CHEK2CDK5CDK5R1CHEK1CCNB2 | |
| Debromohymenialdisine SCHEMBL4303192 | 0.70 | CDK5 (0.70) | CHEK2CDK5CDK5R1CHEK1CCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10821141-B2 | HSV-1 oncolytic virus therapies that specifically kill ALT dependent cancers | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2020-11-03 | — | — | US | disclosed |
| US-20190046594-A1 | HSV-1 ONCOLYTIC VIRUS THERAPIES THAT SPECIFICALLY KILL ALT DEPENDENT CANCERS | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2019-02-14 | — | — | US | disclosed |