Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 9/20 | 0.69 |
| ▸ | CDK5R1 | Q15078 | 9/20 | 0.69 |
| ▸ | CCNB2 | O95067 | 8/20 | 0.69 |
| ▸ | CDK1 | P06493 | 8/20 | 0.69 |
| ▸ | CCNB1 | P14635 | 8/20 | 0.69 |
| ▸ | CCNB3 | Q8WWL7 | 8/20 | 0.69 |
| ▸ | CHEK1 | O14757 | 8/20 | 0.69 |
| ▸ | CHEK2 | O96017 | 7/20 | 0.69 |
| ▸ | RAF1 | P04049 | 4/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.69 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.69 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.69 |
| ▸ | PRKCG | P05129 | 3/20 | 0.69 |
| ▸ | PRKCB | P05771 | 3/20 | 0.69 |
| ▸ | PRKCA | P17252 | 3/20 | 0.69 |
| ▸ | PRKCH | P24723 | 3/20 | 0.69 |
| ▸ | PRKCI | P41743 | 3/20 | 0.69 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.69 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.69 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hymenialdisine SCHEMBL1249687 | 0.96 | CHEK2 (0.74) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| Hymenialdisine SCHEMBL155899 | 0.96 | CHEK2 (0.74) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| Hymenialdisine SCHEMBL1249686 | 0.96 | CHEK2 (0.74) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| Hymenialdisine SCHEMBL20720488 | 0.87 | CHEK2 (0.61) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| Hymenialdisine SCHEMBL18114524 | 0.82 | CDK5 (1.00) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| Hymenialdisine SCHEMBL15426167 | 0.82 | CDK5 (1.00) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| SCHEMBL13592120 | 0.77 | CDK5 (0.46) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| Debromohymenialdisine SCHEMBL4303192 | 0.76 | CDK5 (0.70) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| Debromohymenialdisine SCHEMBL3577997 | 0.76 | CDK5 (0.70) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| Debromohymenialdisine SCHEMBL3578000 | 0.76 | CDK5 (0.70) | CDK5CDK5R1CCNB2CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7098204-B2 | Hymenialdisine or derivatives thereof in the manufacture of medicaments | C.N.R.S. (FR) | 2006-08-29 | — | — | US | disclosed |
| US-20030105075-A1 | Hymenialdisine or derivatives thereof in the manufacture of medicaments | C.N.R.S (FR) | 2003-06-05 | — | — | US | disclosed |
| EP-1235578-A2 | USE OF HYMENIALDISINE OR DERIVATIVES THEREOF IN THE MANUFACTURE OF MEDICAMENTS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2002-09-04 | — | — | EP | disclosed |
| WO-2001041768-A2 | USE OF HYMENIALDISINE OR DERIVATIVES THEREOF IN THE MANUFACTURE OF MEDICAMENTS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2001-06-14 | — | — | WO | disclosed |
| EP-1106180-A1 | Use of hymenialdisine or derivatives thereof in the manufacture of medicaments | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2001-06-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030105075-A1 | Hymenialdisine or derivatives thereof in the manufacture of medicaments | CDK1, CDK3, CSNK1E | CDK5 25/4885CDK5R1 63/4885CCNB2 81/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.