Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.38 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4043065 | 0.82 | ATM (0.39) | ATMTRIM24TRIM33HDAC8 | |
| SCHEMBL2072144 | 0.71 | HDAC8 (0.58) | ATMTRIM24TRIM33HDAC8 | |
| SCHEMBL16271028 | 0.71 | — | — | |
| SCHEMBL6234167 | 0.71 | — | — | |
| SCHEMBL6650788 | 0.71 | TRIM24 (0.61) | ATMTRIM24TRIM33HDAC8 | |
| SCHEMBL5393454 | 0.70 | — | — | |
| SCHEMBL12582112 | 0.67 | ATM (0.40) | ATMTRIM24TRIM33HDAC8 | |
| SCHEMBL5709202 | 0.65 | HDAC8 (0.40) | ATMTRIM24TRIM33HDAC8 | |
| SCHEMBL2400189 | 0.64 | ALDH1A1 (0.41) | ATMTRIM24TRIM33HDAC8 | |
| SCHEMBL16901856 | 0.64 | ATM (0.38) | ATMTRIM24TRIM33HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7863444-B2 | 4-aminopyrrolopyrimidines as kinase inhibitors | ABBOTT LABORATORIES (US) | 2011-01-04 | — | — | US | disclosed |
| EP-1114052-A1 | 4-AMINOPYRROLOPYRIMIDINES AS KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-07-11 | — | — | EP | disclosed |
| WO-2000017202-A1 | 4-AMINOPYRROLOPYRIMIDINES AS KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2000-03-30 | — | — | WO | disclosed |