Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 2/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.39 |
| ▸ | SPHK2 | Q9NRA0 | 3/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22084311 | 0.86 | NPC1 (0.44) | SERPINE1NPC1LMNAALDH1A1MEN1 | |
| SCHEMBL22026948 | 0.86 | NPC1 (0.44) | SERPINE1NPC1LMNAALDH1A1MEN1 | |
| SCHEMBL22084480 | 0.86 | NPC1 (0.44) | SERPINE1NPC1LMNAALDH1A1MEN1 | |
| SCHEMBL19149356 | 0.86 | NPC1 (0.43) | HSD11B1NPC1LMNAALDH1A1MEN1 | |
| SCHEMBL22084145 | 0.81 | HSD11B1 (0.48) | HSD11B1NPC1LMNAMEN1KMT2A | |
| SCHEMBL29287205 | 0.81 | HSD11B1 (0.48) | HSD11B1NPC1LMNAMEN1KMT2A | |
| SCHEMBL18705090 | 0.78 | LMNA (0.63) | SERPINE1HSD11B1NPC1LMNAALDH1A1 | |
| SCHEMBL24139616 | 0.74 | NPC1 (0.48) | HSD11B1NPC1LMNAALDH1A1MEN1 | |
| SCHEMBL19173144 | 0.74 | MEN1 (0.44) | HSD11B1NPC1LMNAALDH1A1MEN1 | |
| SCHEMBL26366441 | 0.74 | LMNA (0.39) | SERPINE1NPC1LMNAALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200197407-A1 | TARGETING KINASES FOR THE TREATMENT OF CANCER METASTASIS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2020-06-25 | — | — | US | disclosed |
| EP-3665482-A1 | TARGETING KINASES FOR THE TREATMENT OF CANCER METASTASIS | Board Of Regents, The University Of Texas System (US) | 2020-06-17 | — | — | EP | disclosed |
| WO-2019033041-A1 | TARGETING KINASES FOR THE TREATMENT OF CANCER METASTASIS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2019-02-14 | — | — | WO | disclosed |