Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 5/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | YAP1 | P46937 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30059991 | 1.00 | RORC (0.47) | RORCACHECA1CA2L3MBTL1 | |
| SCHEMBL20732043 | 1.00 | RORC (0.47) | RORCACHECA1CA2L3MBTL1 | |
| SCHEMBL20722797 | 0.90 | CA1 (0.48) | RORCACHECA1CA2ALDH1A1 | |
| SCHEMBL30061708 | 0.85 | RORC (0.47) | RORCACHEL3MBTL1MEN1KMT2A | |
| SCHEMBL30059845 | 0.85 | ACHE (0.49) | ACHECA1CA2L3MBTL1MEN1 | |
| SCHEMBL21685571 | 0.85 | ACHE (0.49) | ACHECA1CA2L3MBTL1MEN1 | |
| SCHEMBL20722411 | 0.85 | ACHE (0.49) | ACHECA1CA2L3MBTL1MEN1 | |
| SCHEMBL28576430 | 0.84 | CA1 (0.48) | ACHECA1CA2L3MBTL1MEN1 | |
| SCHEMBL20722621 | 0.84 | CA1 (0.48) | ACHECA1CA2L3MBTL1MEN1 | |
| SCHEMBL20722476 | 0.80 | ACHE (0.47) | ACHECA1CA2L3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3665169-A1 | CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | Forma Therapeutics, Inc. (US) | 2020-06-17 | — | — | EP | disclosed |
| WO-2019032863-A1 | CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2019-02-14 | — | — | WO | disclosed |