Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.64 |
| ▸ | PTPRA | P18433 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | ACE | P12821 | 2/20 | 0.57 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.55 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.55 |
| ▸ | ITGAL | P20701 | 1/20 | 0.55 |
| ▸ | CTSL | P07711 | 1/20 | 0.53 |
| ▸ | CTSS | P25774 | 1/20 | 0.53 |
| ▸ | CTSK | P43235 | 1/20 | 0.53 |
| ▸ | TACR1 | P25103 | 2/20 | 0.51 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30076272 | 1.00 | SCN9A (0.64) | SCN9APTPRACYP2C19ACEITGB2 | |
| SCHEMBL20723654 | 1.00 | SCN9A (0.64) | SCN9APTPRACYP2C19ACEITGB2 | |
| SCHEMBL4171190 | 0.92 | ACE (0.57) | SCN9APTPRAACEITGB2ICAM1 | |
| SCHEMBL22091572 | 0.85 | SCN9A (0.69) | SCN9AACECTSLCTSSCTSK | |
| SCHEMBL29842668 | 0.85 | SCN9A (0.69) | SCN9AACEITGB2ICAM1ITGAL | |
| SCHEMBL22734264 | 0.85 | SCN9A (0.69) | SCN9AACEITGB2ICAM1ITGAL | |
| SCHEMBL22734263 | 0.85 | SCN9A (0.69) | SCN9AACEITGB2ICAM1ITGAL | |
| SCHEMBL22091571 | 0.85 | SCN9A (0.69) | SCN9AACECTSLCTSSCTSK | |
| SCHEMBL23051916 | 0.84 | SCN9A (0.68) | SCN9AACEITGB2ICAM1ITGAL | |
| SCHEMBL8502043 | 0.84 | SCN9A (0.68) | SCN9AACEITGB2ICAM1ITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3661938-B1 | NOVEL METHOD FOR SYNTHESIZING AMANITINS | HEIDELBERG PHARMA RES GMBH (DE) | 2025-01-15 | — | — | EP | disclosed |
| US-11926631-B2 | Method of treating cancer using amanitin derivatives | HEIDELBERG PHARMA RESEARCH GMBH (DE) | 2024-03-12 | — | — | US | disclosed |
| CN-110997676-B | Novel method for synthesizing amanitine | 海德堡医药研究有限责任公司 | 2022-12-20 | — | — | CN | disclosed |
| US-20220274995-A1 | NOVEL METHOD FOR SYNTHESIZING AMANITINS | HEIDELBERG PHARMA RESEARCH GMBH (DE) | 2022-09-01 | — | — | US | disclosed |
| US-11420971-B2 | Method for synthesizing amanitins | HEIDELBERG PHARMA RESEARCH GMBH (DE) | 2022-08-23 | — | — | US | disclosed |
| US-20210061805-A1 | NOVEL METHOD FOR SYNTHESIZING AMANITINS | HEIDELBERG PHARMA RESEARCH GMBH (DE) | 2021-03-04 | — | — | US | disclosed |
| EP-3661938-A1 | NOVEL METHOD FOR SYNTHESIZING AMANITINS | Heidelberg Pharma Research GmbH (DE) | 2020-06-10 | — | — | EP | disclosed |
| CN-110997676-A | Novel method for synthesizing amanitin | 海德堡医药研究有限责任公司 | 2020-04-10 | — | — | CN | disclosed |
| WO-2019030171-A1 | NOVEL METHOD FOR SYNTHESIZING AMANITINS | HEIDELBERG PHARMA GMBH (DE) | 2019-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11420971-B2 | Method for synthesizing amanitins | CIAPIN1, AANAT, ANXA5 | SCN9A 4812/4885PTPRA 3869/4885CYP2C19 2467/4885 |
| US-20220274995-A1 | NOVEL METHOD FOR SYNTHESIZING AMANITINS | CIAPIN1, ANXA5, ANXA6 | SCN9A 4793/4885PTPRA 3955/4885CYP2C19 3435/4885 |
| US-11926631-B2 | Method of treating cancer using amanitin derivatives | ANXA5, AADAT, ANXA3 | SCN9A 4794/4885PTPRA 3565/4885CYP2C19 2350/4885 |
| US-20210061805-A1 | NOVEL METHOD FOR SYNTHESIZING AMANITINS | CIAPIN1, ANXA5, ANXA6 | SCN9A 4793/4885PTPRA 3955/4885CYP2C19 3435/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.