Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | DAO | P14920 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | LDHA | P00338 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2270985 | 0.98 | TP53 (0.46) | KDM4ETP53TSHRDAOPOLB | |
| SCHEMBL30056795 | 0.98 | TP53 (0.46) | KDM4ETP53TSHRDAOPOLB | |
| SCHEMBL3894139 | 0.82 | SMN1; SMN2 (0.41) | KDM4ETP53TSHRDAOPOLB | |
| SCHEMBL30839913 | 0.75 | KDM4E (0.45) | KDM4ETP53TSHRDAOPARP1 | |
| SCHEMBL20916716 | 0.74 | KDM4E (0.35) | KDM4ETP53TSHRDAOPARP1 | |
| SCHEMBL29845563 | 0.74 | KDM4E (0.64) | KDM4ETP53TSHRDAOPARP1 | |
| SCHEMBL2270654 | 0.74 | KDM4E (0.64) | KDM4ETP53TSHRDAOPARP1 | |
| SCHEMBL4753544 | 0.73 | CHRM2 (0.37) | KDM4EPOLBPARP1ALDH1A1L3MBTL1 | |
| SCHEMBL22152272 | 0.73 | MAT2A (0.38) | KDM4ETP53ALDH1A1HTTGAA | |
| SCHEMBL29261559 | 0.73 | PARP1 (0.42) | KDM4EPARP1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10202353-B2 | Therapeutic compounds | GILEAD SCIENCES, INC. (US) | 2019-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10202353-B2 | Therapeutic compounds | RPL35, SARS1, HAVCR2 | KDM4E 4403/4885TP53 1990/4885TSHR 4727/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.