Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATIC | P31939 | 13/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.32 |
| ▸ | F9 | P00740 | 1/20 | 0.30 |
| ▸ | F10 | P00742 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20725838 | 0.94 | ATIC (0.51) | ATICJAK2PDE3BPDE3A | |
| SCHEMBL20725712 | 0.85 | ATIC (0.58) | ATICJAK2 | |
| SCHEMBL20725851 | 0.84 | ATIC (0.69) | ATICF10 | |
| SCHEMBL20725872 | 0.84 | ATIC (0.69) | ATICF10 | |
| SCHEMBL20725768 | 0.83 | ATIC (0.56) | ATIC | |
| SCHEMBL20725845 | 0.83 | ATIC (0.60) | ATIC | |
| SCHEMBL20725764 | 0.83 | ATIC (0.69) | ATIC | |
| SCHEMBL20725762 | 0.81 | ATIC (0.58) | ATIC | |
| SCHEMBL20725849 | 0.81 | ATIC (0.73) | ATICJAK2PDE3BPDE3ATNNI3K | |
| SCHEMBL20725749 | 0.80 | ATIC (0.69) | ATIC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3227279-B1 | 1-OXO-1,2-DIHYDROISOQUINOLIN-7-YL-(5-SUBSTITUTED-THIOPHEN-2-YL)-SULFONAMIDE COMPOUNDS, FORMULATIONS CONTAINING THOSE COMPOUNDS, AND THEIR USE AS AICARFT INHIBITORS IN THE TREATMENT OF CANCERS | LILLY CO ELI (US) | 2019-02-13 | — | — | EP | disclosed |