Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAB2 | O43741 | 6/20 | 0.32 |
| ▸ | PRKAG1 | P54619 | 6/20 | 0.32 |
| ▸ | PRKAA2 | P54646 | 6/20 | 0.32 |
| ▸ | PRKAA1 | Q13131 | 6/20 | 0.32 |
| ▸ | PRKAG3 | Q9UGI9 | 6/20 | 0.32 |
| ▸ | PRKAG2 | Q9UGJ0 | 6/20 | 0.32 |
| ▸ | PRKAB1 | Q9Y478 | 6/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.30 |
| ▸ | CFTR | P13569 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20726347 | 0.86 | DHODH (0.38) | PRKAG1PRKAA1PRKAB1CHEK1BRD4 | |
| SCHEMBL20726493 | 0.80 | CHEK1 (0.32) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL16824360 | 0.80 | PRKAB1 (0.34) | PRKAG1PRKAA2PRKAA1PRKAG2PRKAB1 | |
| SCHEMBL30629981 | 0.80 | PRKAB1 (0.34) | PRKAG1PRKAA2PRKAA1PRKAG2PRKAB1 | |
| SCHEMBL16824362 | 0.80 | PRKAB1 (0.34) | PRKAG1PRKAA2PRKAA1PRKAG2PRKAB1 | |
| SCHEMBL20726374 | 0.78 | PRKAB2 (0.45) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL20726469 | 0.77 | PRKAB2 (0.52) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL20726527 | 0.77 | USP2 (0.41) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL20726400 | 0.77 | PRKAB2 (0.49) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL20726426 | 0.77 | PRKAB2 (0.52) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083611-B1 | OXINDOLE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE IN THE TREATMENT OF AMPK-RELATED DISEASES | SANOFI SA (FR) | 2019-02-13 | — | — | EP | disclosed |