Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAB2 | O43741 | 10/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 10/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 10/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 10/20 | 0.39 |
| ▸ | PRKAG3 | Q9UGI9 | 10/20 | 0.39 |
| ▸ | PRKAG2 | Q9UGJ0 | 10/20 | 0.39 |
| ▸ | PRKAB1 | Q9Y478 | 10/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.32 |
| ▸ | PBK | Q96KB5 | 2/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20726365 | 0.90 | PBK (0.41) | KDRNEK1PBK | |
| SCHEMBL20726508 | 0.88 | PRKAB2 (0.46) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL20726398 | 0.88 | PRKAB2 (0.50) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL20726419 | 0.87 | KDR (0.31) | KDRCHEK1 | |
| SCHEMBL20726369 | 0.81 | KDR (0.40) | PRKAA1KDRCHEK1EGFR | |
| SCHEMBL20726485 | 0.78 | ERCC1 (0.40) | KDRCHEK1EGFR | |
| SCHEMBL20726452 | 0.77 | EGFR (0.40) | KDRCHEK1EGFR | |
| SCHEMBL20726449 | 0.77 | SLC6A3 (0.40) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL20726377 | 0.77 | PRKAB2 (0.39) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL20726481 | 0.74 | ERBB2 (0.40) | KDRCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083611-B1 | OXINDOLE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE IN THE TREATMENT OF AMPK-RELATED DISEASES | SANOFI SA (FR) | 2019-02-13 | — | — | EP | disclosed |