Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 3/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.33 |
| ▸ | EZH1 | Q92800 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20727247 | 0.85 | EZH2 (0.44) | EZH2PDE7AEZH1CYP2D6HRH1 | |
| SCHEMBL20727248 | 0.84 | EZH2 (0.45) | EZH2PDE7AEZH1CYP2D6 | |
| SCHEMBL20727204 | 0.81 | EZH2 (0.35) | EZH2EZH1 | |
| SCHEMBL20727230 | 0.80 | S1PR1 (0.34) | EZH2PDE7AEZH1TLR9TLR8 | |
| SCHEMBL20727114 | 0.79 | EZH2 (0.50) | EZH2PDE7AEZH1 | |
| SCHEMBL22351880 | 0.78 | EZH2 (0.51) | EZH2PDE7AEZH1 | |
| SCHEMBL20727196 | 0.76 | HPGDS (0.33) | EZH2TLR9TLR8TLR7 | |
| SCHEMBL22351954 | 0.72 | EZH2 (0.47) | EZH2 | |
| SCHEMBL22351956 | 0.70 | EZH2 (0.43) | EZH2 | |
| SCHEMBL22351897 | 0.69 | EZH2 (0.47) | EZH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3441388-A1 | 4,5,6-TRI-SUBSTITUTED INDAZOLES DERIVATIVES, PREPARATION THEREOF, AND USE THEREOF IN MEDICINES | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. (CN) | 2019-02-13 | — | — | EP | disclosed |