Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | PAK3 | O75914 | 1/20 | 0.32 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.32 |
| ▸ | PAK2 | Q13177 | 1/20 | 0.32 |
| ▸ | EZH2 | Q15910 | 2/20 | 0.31 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.31 |
| ▸ | EZH1 | Q92800 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20727226 | 0.80 | PDE7A (0.36) | S1PR1PAK3PAK1PAK2PDE7A | |
| SCHEMBL20727202 | 0.80 | PDE4B (0.34) | EZH2EZH1 | |
| SCHEMBL20727228 | 0.80 | EZH2 (0.38) | TLR9TLR8TLR7EZH2PDE7A | |
| SCHEMBL20727222 | 0.74 | GRIN2B (0.35) | TLR9TLR8TLR7 | |
| SCHEMBL20727247 | 0.67 | EZH2 (0.44) | EZH2PDE7AEZH1 | |
| SCHEMBL20727248 | 0.67 | EZH2 (0.45) | EZH2PDE7AEZH1 | |
| SCHEMBL15700502 | 0.64 | EZH2 (0.50) | EZH2PDE7AEZH1 | |
| SCHEMBL15647390 | 0.64 | EZH2 (0.50) | EZH2PDE7AEZH1 | |
| SCHEMBL15647389 | 0.64 | EZH2 (0.50) | EZH2PDE7AEZH1 | |
| SCHEMBL20727144 | 0.63 | EZH2 (0.34) | EZH2EZH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3441388-A1 | 4,5,6-TRI-SUBSTITUTED INDAZOLES DERIVATIVES, PREPARATION THEREOF, AND USE THEREOF IN MEDICINES | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. (CN) | 2019-02-13 | — | — | EP | disclosed |