Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.61 |
| ▸ | FTO | Q9C0B1 | 9/20 | 0.58 |
| ▸ | NAALAD2 | Q9Y3Q0 | 2/20 | 0.53 |
| ▸ | RORC | P51449 | 1/20 | 0.52 |
| ▸ | NQO1 | P15559 | 1/20 | 0.49 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.46 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20729952 | 0.89 | FTO (0.58) | TTRFTONAALAD2RORCNQO1 | |
| SCHEMBL23417780 | 0.88 | TTR (0.64) | TTRFTONAALAD2RORCNQO1 | |
| SCHEMBL31542969 | 0.88 | TTR (0.64) | TTRFTONAALAD2RORCNQO1 | |
| SCHEMBL31542972 | 0.88 | TTR (0.64) | TTRFTONAALAD2RORCNQO1 | |
| SCHEMBL27016019 | 0.86 | TTR (0.64) | TTRFTONAALAD2RORCNQO1 | |
| SCHEMBL26430106 | 0.85 | TTR (0.61) | TTRFTONAALAD2RORCNQO1 | |
| SCHEMBL23417940 | 0.85 | TTR (0.63) | TTRFTONAALAD2RORCNQO1 | |
| SCHEMBL25045451 | 0.85 | TTR (0.63) | TTRFTONAALAD2RORCNQO1 | |
| SCHEMBL23417716 | 0.84 | TTR (0.60) | TTRFTONAALAD2RORCNQO1 | |
| SCHEMBL15271674 | 0.84 | TTR (0.60) | TTRFTONAALAD2RORCNQO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019030284-A1 | NEW TARGETED CYTOTOXIC RATJADONE DERIVATIVES AND CONJUGATES THEREOF | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2019-02-14 | — | — | WO | disclosed |