Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 4/20 | 0.59 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 3/20 | 0.49 |
| ▸ | IGF1R | P08069 | 2/20 | 0.49 |
| ▸ | APP | P05067 | 2/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5652869 | 0.86 | FYN (0.44) | FYNMAP4K4 | |
| SCHEMBL24729874 | 0.82 | ALDH1A1 (0.52) | FYNMAP4K4HDAC3HDAC1HDAC2 | |
| SCHEMBL23938205 | 0.82 | HDAC3 (0.51) | FYNMAP4K4HDAC3HDAC1HDAC2 | |
| SCHEMBL7231916 | 0.81 | FABP1 (0.58) | FYNMAP4K4EGFRHDAC3HDAC1 | |
| SCHEMBL5648300 | 0.81 | CLK4 (0.47) | FYNHRH4TAAR1 | |
| SCHEMBL15355682 | 0.80 | KDM1A (0.55) | FYNMAP4K4EGFRHDAC3HDAC1 | |
| SCHEMBL1290643 | 0.80 | KDM1A (0.55) | FYNMAP4K4EGFRHDAC3HDAC1 | |
| SCHEMBL1290644 | 0.80 | KDM1A (0.55) | FYNMAP4K4EGFRHDAC3HDAC1 | |
| Hydrochloric Acid SCHEMBL1290710 | 0.79 | KDM1A (0.54) | FYNMAP4K4HDAC3HDAC1HDAC2 | |
| Hydrochloric Acid SCHEMBL1290708 | 0.79 | KDM1A (0.54) | FYNMAP4K4HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020033707-A1 | CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2020-02-13 | — | — | WO | disclosed |
| WO-2019032863-A1 | CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2019-02-14 | — | — | WO | disclosed |