Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 4/20 | 0.47 |
| ▸ | VNN1 | O95497 | 2/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.43 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22191269 | 0.84 | HDAC3 (0.63) | HDAC3HDAC1HDAC2HDAC6MAP4K4 | |
| SCHEMBL24729874 | 0.82 | ALDH1A1 (0.52) | HDAC3HDAC1HDAC2HDAC6MAP4K4 | |
| SCHEMBL20731983 | 0.82 | FYN (0.59) | HDAC3HDAC1HDAC2HDAC6MAP4K4 | |
| SCHEMBL22191739 | 0.81 | FABP1 (0.58) | HDAC3HDAC1HDAC2HDAC6VNN1 | |
| SCHEMBL23938195 | 0.79 | HDAC3 (0.54) | HDAC3HDAC1HDAC2HDAC6MAP4K4 | |
| SCHEMBL24457942 | 0.78 | FFAR1 (0.49) | GAA | |
| SCHEMBL11567300 | 0.78 | HDAC3 (0.60) | HDAC3HDAC1HDAC2HDAC6VNN1 | |
| SCHEMBL23938199 | 0.77 | KDM4E (0.69) | HDAC3HDAC1HDAC2HDAC6MAP4K4 | |
| SCHEMBL29580199 | 0.77 | KDM4E (0.69) | HDAC3HDAC1HDAC2HDAC6MAP4K4 | |
| SCHEMBL20874965 | 0.76 | APP (0.48) | HDAC3HDAC1HDAC2HDAC6MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11524966-B1 | Carboxamides as ubiquitin-specific protease inhibitors | VALO HEALTH, INC. (US) | 2022-12-13 | — | — | US | disclosed |
| US-20210323975-A1 | CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | VALO EARLY DISCOVERY, INC. | 2021-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11524966-B1 | Carboxamides as ubiquitin-specific protease inhibitors | USP28, USP25, USP24 | HDAC3 160/4885HDAC1 130/4885HDAC2 121/4885 |
| US-20210323975-A1 | CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | USP28, USP25, USP24 | HDAC3 160/4885HDAC1 130/4885HDAC2 121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.