Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 12/20 | 0.37 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | CBLB | Q13191 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20733196 | 0.87 | GSK3B (0.38) | FGFR4 | |
| SCHEMBL20733310 | 0.85 | ALDH1A1 (0.35) | FGFR4 | |
| SCHEMBL20733152 | 0.82 | FGFR4 (0.36) | FGFR4FGFR1 | |
| SCHEMBL17769366 | 0.77 | CNR2 (0.33) | — | |
| SCHEMBL17769368 | 0.77 | CNR2 (0.33) | — | |
| SCHEMBL17777016 | 0.77 | AXL (0.33) | CBLB | |
| SCHEMBL17770122 | 0.77 | AXL (0.33) | CBLB | |
| SCHEMBL17770116 | 0.77 | AXL (0.33) | CBLB | |
| SCHEMBL17770184 | 0.77 | AXL (0.33) | CBLB | |
| SCHEMBL20733268 | 0.76 | AXL (0.32) | FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190048016-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2019-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190048016-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | FGFR4 1926/4885RIOK2 2619/4885RPS6KA3 1949/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.