Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 7/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ACACA | Q13085 | 4/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.32 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17778481 | 0.80 | MAPK8 (0.43) | ACACBL3MBTL1CHEK1MAPK8KDM4E | |
| SCHEMBL19699558 | 0.73 | CHEK1 (0.41) | CHEK1KDM4EADORA3ADORA2ALPAR1 | |
| SCHEMBL19706540 | 0.71 | MAPK8 (0.44) | L3MBTL1MAPK8KDM4EHSP90AA1HSP90AB1 | |
| SCHEMBL19706526 | 0.70 | MAPK8 (0.46) | L3MBTL1MAPK8KDM4EHSP90AA1HSP90AB1 | |
| SCHEMBL17776544 | 0.70 | MAPK8 (0.39) | L3MBTL1CHEK1MAPK8KDM4EHSP90AA1 | |
| SCHEMBL17778558 | 0.69 | CHEK1 (0.40) | ACACBMAPK1CHEK1ADORA3ADORA2A | |
| SCHEMBL19699593 | 0.68 | ADORA3 (0.37) | CHEK1MAPK8ADORA3ADORA2AMAPK9 | |
| SCHEMBL19706551 | 0.67 | MAPK8 (0.63) | L3MBTL1MAPK8KDM4EHSP90AA1HSP90AB1 | |
| SCHEMBL19699607 | 0.67 | ADORA3 (0.40) | CHEK1MAPK8ADORA3ADORA2AMAPK9 | |
| SCHEMBL17776548 | 0.66 | MAPK8 (0.58) | ACACBL3MBTL1MAPK8KDM4EHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190048016-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2019-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190048016-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | ACACB 306/4885MAPK1 1369/4885L3MBTL1 3276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.