Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.69 |
| ▸ | NPC1 | O15118 | 1/20 | 0.69 |
| ▸ | BRD4 | O60885 | 1/20 | 0.66 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.66 |
| ▸ | OGG1 | O15527 | 5/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22104615 | 0.85 | RAB9A (0.66) | RAB9ANPC1BRD4ATAD2OGG1 | |
| SCHEMBL20733380 | 0.84 | OGG1 (0.67) | RAB9ANPC1BRD4ATAD2OGG1 | |
| SCHEMBL20733385 | 0.80 | RAB9A (0.69) | RAB9ANPC1BRD4ATAD2OGG1 | |
| SCHEMBL17117541 | 0.80 | BRD4 (0.71) | RAB9ANPC1BRD4ATAD2OGG1 | |
| SCHEMBL16771416 | 0.80 | BRD4 (1.00) | RAB9ANPC1BRD4ATAD2OGG1 | |
| SCHEMBL22104625 | 0.79 | OGG1 (0.83) | RAB9ANPC1BRD4ATAD2OGG1 | |
| SCHEMBL22104718 | 0.77 | OGG1 (0.74) | RAB9ANPC1BRD4ATAD2OGG1 | |
| SCHEMBL22104699 | 0.77 | OGG1 (0.77) | RAB9ANPC1BRD4ATAD2OGG1 | |
| SCHEMBL22104657 | 0.77 | OGG1 (0.74) | RAB9ANPC1BRD4ATAD2OGG1 | |
| SCHEMBL17005768 | 0.77 | SYK (0.62) | RAB9ANPC1BRD4ATAD2OGG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019032563-A1 | INHIBITORS OF BASE EXCISION REPAIR ACTIVITY AND THERAPEUTIC METHODS BASED THEREON | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2019-02-14 | — | — | WO | disclosed |