Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2074790 | 0.99 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1RAB9AGSK3BDYRK1A | |
| SCHEMBL2075861 | 0.99 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1RAB9AGSK3BDYRK1A | |
| SCHEMBL2074244 | 0.90 | NPC1 (0.53) | SMN1; SMN2ALDH1A1RAB9AGSK3BDYRK1A | |
| SCHEMBL2075431 | 0.89 | LMNA (0.43) | SMN1; SMN2ALDH1A1RAB9AGSK3BDYRK1A | |
| SCHEMBL2075500 | 0.87 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1RAB9AGSK3BDYRK1A | |
| SCHEMBL2074903 | 0.85 | HRH3 (0.49) | SMN1; SMN2ALDH1A1LOXL2NPC1ATM | |
| SCHEMBL2072344 | 0.84 | CNR2 (0.43) | SMN1; SMN2ALDH1A1RAB9AGSK3BDYRK1A | |
| SCHEMBL2073004 | 0.83 | KIT (0.49) | SMN1; SMN2ALDH1A1RAB9APDGFRBLOXL2 | |
| SCHEMBL2075158 | 0.82 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1RAB9ANPC1ATM | |
| SCHEMBL2072493 | 0.82 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1RAB9AGSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7902184-B2 | Piperazinyl pyrimidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-03-08 | — | — | US | claimed |
| US-7902184-B2 | Piperazinyl pyrimidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-03-08 | — | — | US | disclosed |