Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | CTSA | P10619 | 1/20 | 0.33 |
| ▸ | APLNR | P35414 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2600726 | 0.80 | NOS1 (0.44) | NOS1CTSAAPLNRALDH1A1GAA | |
| SCHEMBL3248176 | 0.76 | NOS1 (0.46) | NOS1CTSAAPLNRALDH1A1GAA | |
| SCHEMBL11458946 | 0.76 | NOS1 (0.41) | NOS1CTSAAPLNRALDH1A1GAA | |
| SCHEMBL12179230 | 0.76 | NOS1 (0.41) | NOS1CTSAAPLNRALDH1A1GAA | |
| SCHEMBL30209038 | 0.76 | NOS1 (0.46) | NOS1CTSAAPLNRALDH1A1GAA | |
| SCHEMBL23869812 | 0.76 | NOS1 (0.41) | NOS1CTSAAPLNRALDH1A1GAA | |
| SCHEMBL6010207 | 0.76 | NOS1 (0.41) | NOS1CTSAAPLNRALDH1A1GAA | |
| SCHEMBL29271546 | 0.73 | NOS1 (0.43) | NOS1CTSAAPLNR | |
| SCHEMBL12848866 | 0.73 | NOS1 (0.38) | NOS1CTSAAPLNR | |
| SCHEMBL9923027 | 0.71 | NOS1 (0.37) | NOS1CTSAAPLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230019032-A1 | BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2023-01-19 | — | — | US | disclosed |
| US-11001575-B1 | Benzolactam compounds as protein kinase inhibitors | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2021-05-11 | — | — | US | disclosed |
| US-10457669-B2 | Benzolactam compounds as protein kinase inhibitors | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2019-10-29 | — | — | US | disclosed |
| US-20190047990-A1 | BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2019-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230019032-A1 | BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS | MAPK1, ALK, MAP3K1 | NOS1 774/4885CTSA 3870/4885APLNR 2588/4885 |
| US-20190047990-A1 | BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS | MAPK1, ALK, MAP3K1 | NOS1 774/4885CTSA 3870/4885APLNR 2588/4885 |
| US-11001575-B1 | Benzolactam compounds as protein kinase inhibitors | MAPK1, ALK, MAP3K1 | NOS1 787/4885CTSA 3739/4885APLNR 2521/4885 |
| US-10457669-B2 | Benzolactam compounds as protein kinase inhibitors | MAPK1, ALK, MAP3K1 | NOS1 774/4885CTSA 3870/4885APLNR 2588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.