Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 19/20 | 1.00 |
| ▸ | IL6 | P05231 | 6/20 | 0.80 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30503510 | 0.91 | TLR7 (0.84) | TLR7IL6 | |
| SCHEMBL22347124 | 0.91 | TLR7 (0.84) | TLR7IL6 | |
| SCHEMBL1145915 | 0.91 | TLR7 (0.84) | TLR7IL6NUDT1 | |
| Hydrochloric Acid SCHEMBL1146402 | 0.90 | TLR7 (0.82) | TLR7IL6NUDT1 | |
| SCHEMBL26354073 | 0.90 | TLR7 (0.82) | TLR7IL6 | |
| SCHEMBL29381054 | 0.89 | TLR7 (1.00) | TLR7IL6NUDT1 | |
| SCHEMBL1641626 | 0.89 | TLR7 (1.00) | TLR7IL6NUDT1 | |
| SCHEMBL1146322 | 0.89 | TLR7 (0.79) | TLR7IL6NUDT1 | |
| SCHEMBL24247632 | 0.89 | TLR7 (0.82) | TLR7IL6 | |
| SCHEMBL1146578 | 0.89 | TLR7 (0.79) | TLR7IL6NUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111201228-B | 6-amino-7, 9-dihydro-8H-purin-8-one derivatives as Toll-like receptor 7 (TLR 7) agonists | 百时美施贵宝公司 | 2024-04-09 | — | — | CN | disclosed |
| CN-111032657-B | 6-amino-7, 9-dihydro-8H-purin-8-one derivatives as immunostimulant Toll-like receptor 7 (TLR 7) agonists | 百时美施贵宝公司 | 2024-03-29 | — | — | CN | disclosed |
| CN-111225918-B | Toll-like receptor 7 (TLR 7) agonists with tricyclic moieties, conjugates thereof, methods and uses thereof | 百时美施贵宝公司 | 2024-01-19 | — | — | CN | disclosed |
| EP-3668872-B1 | 6-AMINO-7,9-DIHYDRO-8H-PURIN-8-ONE DERIVATIVES AS IMMUNOSTIMULANT TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2022-02-23 | — | — | EP | disclosed |
| EP-3668869-B1 | 6-AMINO-7,9-DIHYDRO-8H-PURIN-8-ONE DERIVATIVES AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS AS IMMUNOSTIMULANTS | BRISTOL MYERS SQUIBB CO (US) | 2022-01-12 | — | — | EP | disclosed |
| EP-3668870-B1 | 6-AMINO-7,9-DIHYDRO-8H-PURIN-8-ONE DERIVATIVES AS IMMUNOSTIMULANT TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2021-12-08 | — | — | EP | disclosed |
| EP-3668868-B1 | TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS HAVING A TRICYCLIC MOIETY, CONJUGATES THEREOF, AND METHODS AND USES THEREFOR | BRISTOL MYERS SQUIBB CO (US) | 2021-09-22 | — | — | EP | disclosed |
| EP-3668871-B1 | 6-AMINO-7,9-DIHYDRO-8H-PURIN-8-ONE DERIVATIVES AS IMMUNOSTIMULANT TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2021-08-04 | — | — | EP | disclosed |
| US-10981914-B2 | Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor | Bristol-Myers Squibb Companay (US) | 2021-04-20 | — | — | US | disclosed |
| US-10941145-B2 | Toll-like receptor 7 (TLR7) agonists having a benzotriazole moiety, conjugates thereof, and methods and uses therefor | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-03-09 | — | — | US | disclosed |
| US-10457681-B2 | Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor | Bristol_Myers Squibb Company (US) | 2019-10-29 | — | — | US | disclosed |
| US-20190055245-A1 | TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS HAVING A PYRIDINE OR PYRAZINE MOIETY, CONJUGATES THEREOF, AND METHODS AND USES THEREFOR | BRISTOL-MYERS SQUIBB COMPANY | 2019-02-21 | — | — | US | disclosed |
| US-20190055243-A1 | TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS HAVING A BENZOTRIAZOLE MOIETY, CONJUGATES THEREOF, AND METHODS AND USES THEREFOR | BRISTOL-MYERS SQUIBB COMPANY | 2019-02-21 | — | — | US | disclosed |
| US-20190055247-A1 | TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS HAVING HETEROATOM-LINKED AROMATIC MOIETIES, CONJUGATES THEREOF, AND METHODS AND USES THEREFOR | BRISTOL-MYERS SQUIBB COMPANY | 2019-02-21 | — | — | US | disclosed |
| US-20190055244-A1 | TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS HAVING A TRICYCLIC MOIETY, CONJUGATES THEREOF, AND METHODS AND USES THEREFOR | BRISTOL-MYERS SQUIBB COMPANY | 2019-02-21 | — | — | US | disclosed |
| WO-2019035968-A1 | 6-AMINO-7,9-DIHYDRO-8H-PURIN-8-ONE DERIVATIVES AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS AS IMMUNOSTIMULANTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-02-21 | — | — | WO | disclosed |
| WO-2019035969-A1 | TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS HAVING A TRICYCLIC MOIETY, CONJUGATES THEREOF, AND METHODS AND USES THEREFOR | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-02-21 | — | — | WO | disclosed |
| WO-2019035971-A1 | 6-AMINO-7,9-DIHYDRO-8H-PURIN-8-ONE DERIVATIVES AS IMMUNOSTIMULANT TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-02-21 | — | — | WO | disclosed |
| US-20190055246-A1 | TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS HAVING A HETEROBIARYL MOIETY, CONJUGATES THEREOF, AND METHODS AND USES THEREFOR | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-02-21 | — | — | US | disclosed |
| WO-2019035970-A1 | 6-AMINO-7,9-DIHYDRO-8H-PURIN-8-ONE DERIVATIVES AS IMMUNOSTIMULANT TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-02-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10941145-B2 | Toll-like receptor 7 (TLR7) agonists having a benzotriazole moiety, conjugates thereof, and methods and uses therefor | TLR7, TLR1, TLR4 | TLR7 1/4885IL6 601/4885NUDT1 1575/4885 |
| US-20190055243-A1 | TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS HAVING A BENZOTRIAZOLE MOIETY, CONJUGATES THEREOF, AND METHODS AND USES THEREFOR | TLR7, TLR1, TLR4 | TLR7 1/4885IL6 601/4885NUDT1 1575/4885 |
| US-10981914-B2 | Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor | TLR7, TLR1, TLR4 | TLR7 1/4885IL6 752/4885NUDT1 2820/4885 |
| US-20190055244-A1 | TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS HAVING A TRICYCLIC MOIETY, CONJUGATES THEREOF, AND METHODS AND USES THEREFOR | TLR7, TLR1, TLR4 | TLR7 1/4885IL6 760/4885NUDT1 2627/4885 |
| US-20190055245-A1 | TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS HAVING A PYRIDINE OR PYRAZINE MOIETY, CONJUGATES THEREOF, AND METHODS AND USES THEREFOR | TLR7, TLR1, TLR4 | TLR7 1/4885IL6 329/4885NUDT1 2124/4885 |
| US-20190055246-A1 | TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS HAVING A HETEROBIARYL MOIETY, CONJUGATES THEREOF, AND METHODS AND USES THEREFOR | TLR7, TLR9, TLR1 | TLR7 1/4885IL6 562/4885NUDT1 2474/4885 |
| US-20190055247-A1 | TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS HAVING HETEROATOM-LINKED AROMATIC MOIETIES, CONJUGATES THEREOF, AND METHODS AND USES THEREFOR | TLR7, TLR1, TLR8 | TLR7 1/4885IL6 577/4885NUDT1 1567/4885 |
| US-10457681-B2 | Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor | TLR7, TLR1, TLR4 | TLR7 1/4885IL6 760/4885NUDT1 2627/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.