Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCND3 | P30281 | 18/20 | 0.61 |
| ▸ | CDK6 | Q00534 | 18/20 | 0.61 |
| ▸ | CDK4 | P11802 | 12/20 | 0.61 |
| ▸ | CDK9 | P50750 | 11/20 | 0.61 |
| ▸ | CCND1 | P24385 | 11/20 | 0.61 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.61 |
| ▸ | CDK7 | P50613 | 3/20 | 0.61 |
| ▸ | CCNH | P51946 | 3/20 | 0.61 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.61 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.61 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.61 |
| ▸ | CCNK | O75909 | 7/20 | 0.60 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.57 |
| ▸ | CDK2 | P24941 | 6/20 | 0.57 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.57 |
| ▸ | CDK1 | P06493 | 3/20 | 0.55 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.53 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29684118 | 0.86 | CDK6 (0.58) | CCND3CDK6CDK4CDK9CCND1 | |
| SCHEMBL23296218 | 0.86 | CDK6 (0.58) | CCND3CDK6CDK4CDK9CCND1 | |
| SCHEMBL30012234 | 0.85 | CDK2 (0.54) | CCND3CDK6CDK4CDK9CCND1 | |
| SCHEMBL22413899 | 0.82 | CDK4 (0.57) | CCND3CDK6CDK4CDK9CCND1 | |
| SCHEMBL23296202 | 0.82 | CDK4 (0.64) | CCND3CDK6CDK4CDK9CCND1 | |
| SCHEMBL4078840 | 0.80 | EGFR (0.60) | CDK4CDK2CCNE1 | |
| SCHEMBL29557336 | 0.80 | CDK4 (0.59) | CCND3CDK6CDK4CDK9CCND1 | |
| SCHEMBL16840715 | 0.80 | CCND3 (0.50) | CCND3CDK6CDK4CDK9CCND1 | |
| SCHEMBL19882691 | 0.79 | CCND3 (0.51) | CCND3CDK6CDK4CDK9CCND1 | |
| SCHEMBL30541017 | 0.78 | CDK6 (0.62) | CCND3CDK6CDK4CDK9CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11351170-B2 | Substituted pyrimidines as CDK4/6 inhibitors | BEIJING XUANYI PHARMASCIENCES CO., LTD. (CN) | 2022-06-07 | — | — | US | disclosed |
| US-20210128555-A1 | CDK4/6 INHIBITORS AND USE THEREOF | BEIJING XUANYI PHARMASCIENCES CO., LTD. (CN) | 2021-05-06 | — | — | US | disclosed |
| WO-2019035008-A1 | CDK4/6 INHIBITORS AND USE THEREOF | BEIJING XUANYI PHARMASCIENCES CO., LTD. (CN) | 2019-02-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11351170-B2 | Substituted pyrimidines as CDK4/6 inhibitors | CDK4, CDK6, CDK2 | CCND3 41/4885CDK6 2/4885CDK4 1/4885 |
| US-20210128555-A1 | CDK4/6 INHIBITORS AND USE THEREOF | CDK4, CDK6, CDK1 | CCND3 38/4885CDK6 2/4885CDK4 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.