Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 7/20 | 0.57 |
| ▸ | CDK2 | P24941 | 7/20 | 0.57 |
| ▸ | CCND1 | P24385 | 6/20 | 0.57 |
| ▸ | CCND3 | P30281 | 6/20 | 0.57 |
| ▸ | CDK6 | Q00534 | 6/20 | 0.57 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.57 |
| ▸ | CDK1 | P06493 | 5/20 | 0.57 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.57 |
| ▸ | CDK7 | P50613 | 4/20 | 0.57 |
| ▸ | CCNH | P51946 | 4/20 | 0.57 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.57 |
| ▸ | CDK9 | P50750 | 4/20 | 0.57 |
| ▸ | CTSC | P53634 | 1/20 | 0.55 |
| ▸ | WNT3A | P56704 | 8/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27315749 | 0.83 | WNT3A (0.55) | CDK2CCND3CDK6CCNA2CDK9 | |
| SCHEMBL20744489 | 0.82 | CCND3 (0.61) | CDK4CDK2CCND1CCND3CDK6 | |
| SCHEMBL30012234 | 0.79 | CDK2 (0.54) | CDK4CDK2CCND1CCND3CDK6 | |
| SCHEMBL29544087 | 0.79 | CDK2 (0.82) | CDK4CDK2CCND1CCND3CDK6 | |
| SCHEMBL21152705 | 0.79 | WNT3A (0.50) | CDK4WNT3A | |
| SCHEMBL30777173 | 0.78 | CDK4 (0.78) | CDK4CDK2CCND1CCND3CDK6 | |
| SCHEMBL20452169 | 0.78 | CDK4 (0.78) | CDK4CDK2CCND1CCND3CDK6 | |
| SCHEMBL18453164 | 0.78 | WNT3A (0.53) | WNT3A | |
| SCHEMBL23296202 | 0.77 | CDK4 (0.64) | CDK4CDK2CCND1CCND3CDK6 | |
| SCHEMBL24483253 | 0.77 | CDK6 (0.63) | CDK4CDK2CCND1CCND3CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200283431-A1 | N-(PYRIDIN-2-YL)-4-(THIAZOL-5-YL)PYRIMIDIN-2-AMINE DERIVATIVES AS THERAPEUTIC COMPOUNDS | AUCENTRA THERAPEUTICS PTY LTD (AU) | 2020-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200283431-A1 | N-(PYRIDIN-2-YL)-4-(THIAZOL-5-YL)PYRIMIDIN-2-AMINE DERIVATIVES AS THERAPEUTIC COMPOUNDS | CDK4, CDK6, CDKL2 | CDK4 1/4885CDK2 4/4885CCND1 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.