Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 4/20 | 0.45 |
| ▸ | REN | P00797 | 2/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
| ▸ | HTR1B | P28222 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL837183 | 0.77 | BCHE (0.50) | BCHEAHRMCHR1PPARGPPARD | |
| SCHEMBL3870264 | 0.74 | BCHE (0.48) | BCHERENAHRADORA1KEAP1 | |
| SCHEMBL859924 | 0.72 | BCHE (0.51) | BCHEAHRMCHR1KEAP1PPARG | |
| SCHEMBL593890 | 0.72 | BCHE (0.54) | BCHERENAHRKEAP1NR3C1 | |
| SCHEMBL16061100 | 0.71 | MAPT (0.40) | KEAP1PPARGPPARAHTR1B | |
| SCHEMBL6509825 | 0.69 | LMNA (0.40) | MCHR1HTR1DHTR1B | |
| SCHEMBL5074488 | 0.69 | CA1 (0.42) | AR | |
| SCHEMBL6585052 | 0.69 | MEN1 (0.40) | HTR1A | |
| SCHEMBL16417118 | 0.69 | CYP1A2 (0.56) | BCHEMCHR1 | |
| SCHEMBL594125 | 0.69 | BCHE (0.56) | BCHEAHRMCHR1KEAP1NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3668877-A1 | INDOLE DERIVATIVES AS HISTONE DEMETHYLASE INHIBITORS | Istituto Europeo di Oncologia S.r.l. (IT) | 2020-06-24 | — | — | EP | disclosed |
| WO-2019034774-A1 | INDOLE DERIVATIVES AS HISTONE DEMETHYLASE INHIBITORS | ISTITUTO EUROPEO DI ONCOLOGIA (IEO) S.R.L. (IT) | 2019-02-21 | — | — | WO | disclosed |