Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2154404 | 0.76 | ALDH1A1 (0.43) | ALDH1A1KDM1A | |
| SCHEMBL17446896 | 0.75 | — | — | |
| SCHEMBL1504251 | 0.74 | — | — | |
| SCHEMBL11586410 | 0.70 | — | — | |
| SCHEMBL16419574 | 0.70 | ALDH1A1 (0.39) | ALDH1A1 | |
| SCHEMBL3840377 | 0.70 | ALDH1A1 (0.33) | ALDH1A1KDM1A | |
| SCHEMBL20724937 | 0.70 | OPRM1 (0.31) | OPRM1OPRL1 | |
| SCHEMBL7171314 | 0.70 | NPC1 (0.32) | OPRM1OPRL1 | |
| SCHEMBL17445671 | 0.70 | OPRM1 (0.31) | OPRM1OPRL1 | |
| SCHEMBL23549092 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3668858-A1 | PYRAZOLO[1,5-A]PYRAZIN-4-YL AND RELATED DERIVATIVES | Pfizer Inc (US) | 2020-06-24 | — | — | EP | claimed |
| WO-2019034973-A1 | PYRAZOLO[1,5-A]PYRAZIN-4-YL AND RELATED DERIVATIVES | PFIZER INC. (US) | 2019-02-21 | — | — | WO | claimed |