Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | GBA1 | P04062 | 2/20 | 0.43 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.40 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16765922 | 1.00 | HDAC11 (0.46) | HDAC11MAPTSIGMAR1GBA1SPHK2 | |
| SCHEMBL20745637 | 0.84 | MAPT (0.42) | MAPT | |
| SCHEMBL20745635 | 0.84 | MAPT (0.42) | MAPT | |
| Ammonia Solution, Strong SCHEMBL27989210 | 0.84 | CA1 (0.43) | — | |
| SCHEMBL20734689 | 0.83 | SIGMAR1 (0.55) | MAPTSIGMAR1GBA1SPHK2SPHK1 | |
| SCHEMBL6942852 | 0.82 | MAPT (0.50) | HDAC11MAPTSIGMAR1GBA1 | |
| SCHEMBL5371008 | 0.82 | MAPT (0.50) | HDAC11MAPTSIGMAR1GBA1 | |
| SCHEMBL10130060 | 0.82 | MAPT (0.50) | HDAC11MAPTSIGMAR1GBA1 | |
| SCHEMBL15325592 | 0.82 | MAPT (0.50) | HDAC11MAPTSIGMAR1GBA1 | |
| SCHEMBL24938856 | 0.81 | MAPT (0.53) | HDAC11MAPTSIGMAR1GBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3668863-A1 | TRICYCLIC COMPOUNDS AS HISTONE METHYL-TRANSFERASE INHIBITORS | Global Blood Therapeutics, Inc. (US) | 2020-06-24 | — | — | EP | disclosed |
| WO-2019036377-A1 | TRICYCLIC COMPOUNDS AS HISTONE METHYL-TRANSFERASE INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2019-02-21 | — | — | WO | disclosed |