Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 6/20 | 0.51 |
| ▸ | MAOB | P27338 | 6/20 | 0.51 |
| ▸ | GRM6 | O15303 | 1/20 | 0.49 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.45 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20745461 | 1.00 | MAOA (0.51) | MAOAMAOBGRM6AGTR2S1PR5 | |
| SCHEMBL23243788 | 1.00 | MAOA (0.51) | MAOAMAOBGRM6AGTR2S1PR5 | |
| SCHEMBL14555989 | 1.00 | MAOA (0.51) | MAOAMAOBGRM6AGTR2S1PR5 | |
| SCHEMBL16764924 | 1.00 | MAOA (0.51) | MAOAMAOBGRM6AGTR2S1PR5 | |
| SCHEMBL7067401 | 0.88 | MAOB (0.64) | MAOAMAOBGRM6 | |
| SCHEMBL28218104 | 0.88 | MAOB (0.64) | MAOAMAOBGRM6 | |
| Hydrochloric Acid SCHEMBL28218107 | 0.87 | MAOB (0.63) | MAOAMAOBGRM6 | |
| SCHEMBL16764868 | 0.85 | MAOA (0.47) | MAOAMAOBMAPT | |
| SCHEMBL4247443 | 0.85 | MAOA (0.47) | MAOAMAOBMAPT | |
| SCHEMBL28431385 | 0.85 | MAOA (0.47) | MAOAMAOBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3668863-A1 | TRICYCLIC COMPOUNDS AS HISTONE METHYL-TRANSFERASE INHIBITORS | Global Blood Therapeutics, Inc. (US) | 2020-06-24 | — | — | EP | disclosed |
| WO-2019036377-A1 | TRICYCLIC COMPOUNDS AS HISTONE METHYL-TRANSFERASE INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2019-02-21 | — | — | WO | disclosed |