Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 8/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 8/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 8/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.30 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.30 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25346159 | 0.80 | CSNK2A2 (0.37) | CSNK2A2CSNK2BCSNK2A1HTR2CKDM4E | |
| SCHEMBL31155205 | 0.80 | CSNK2A2 (0.37) | CSNK2A2CSNK2BCSNK2A1HTR2CKDM4E | |
| SCHEMBL8172184 | 0.77 | KDM4E (0.39) | CSNK2A2CSNK2BCSNK2A1HTR2CKDM4E | |
| SCHEMBL6240033 | 0.77 | CSNK2A2 (0.35) | CSNK2A2CSNK2BCSNK2A1HTR2CKDM4E | |
| SCHEMBL5198824 | 0.73 | SMN1; SMN2 (0.36) | CSNK2A2CSNK2BCSNK2A1HTR2CKDM4E | |
| SCHEMBL3357775 | 0.70 | NOS3 (0.37) | CSNK2A2CSNK2BCSNK2A1HTR2CKDM4E | |
| SCHEMBL4773700 | 0.69 | MAPT (0.39) | KDM4EMAPTALDH1A1 | |
| SCHEMBL4769008 | 0.66 | KDM4E (0.46) | KDM4EMAPTALDH1A1HPGDHTT | |
| SCHEMBL29792714 | 0.65 | HTR2C (0.45) | HTR2CKDM4EMAPTALDH1A1HPGD | |
| SCHEMBL760085 | 0.65 | HTR2C (0.45) | HTR2CKDM4EMAPTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3652184-A1 | MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE | AbbVie Inc. (US) | 2020-05-20 | — | — | EP | disclosed |
| WO-2019035911-A1 | MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE | ABBVIE INC. (US) | 2019-02-21 | — | — | WO | disclosed |