Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 4/20 | 0.53 |
| ▸ | EHMT2 | Q96KQ7 | 8/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20745999 | 0.92 | ACHE (0.56) | ACHETP53EHMT2SMN1; SMN2POLB | |
| SCHEMBL20745788 | 0.91 | EHMT2 (0.54) | ACHETP53EHMT2SMN1; SMN2POLB | |
| SCHEMBL20745736 | 0.91 | EHMT2 (0.54) | ACHETP53EHMT2SMN1; SMN2POLB | |
| SCHEMBL31458727 | 0.90 | ACHE (0.69) | ACHETP53EHMT2MAPTAPP | |
| SCHEMBL20745564 | 0.90 | ACHE (0.69) | ACHETP53EHMT2MAPTAPP | |
| SCHEMBL20745971 | 0.87 | ACHE (0.74) | ACHETP53EHMT2SMN1; SMN2MAPT | |
| SCHEMBL20756932 | 0.86 | ACHE (0.72) | ACHETP53EHMT2SMN1; SMN2MAPT | |
| SCHEMBL25489623 | 0.83 | ACHE (0.57) | ACHETP53EHMT2SMN1; SMN2POLB | |
| SCHEMBL20745712 | 0.82 | ACHE (0.56) | ACHETP53EHMT2SMN1; SMN2POLB | |
| SCHEMBL20745874 | 0.82 | ACHE (0.56) | ACHETP53EHMT2SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3668863-A1 | TRICYCLIC COMPOUNDS AS HISTONE METHYL-TRANSFERASE INHIBITORS | Global Blood Therapeutics, Inc. (US) | 2020-06-24 | — | — | EP | disclosed |
| WO-2019036377-A1 | TRICYCLIC COMPOUNDS AS HISTONE METHYL-TRANSFERASE INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2019-02-21 | — | — | WO | disclosed |