Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.37 |
| ▸ | TUBB | P07437 | 1/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.37 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.37 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.37 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.37 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.37 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.37 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.37 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.37 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.37 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2881654 | 0.80 | ALDH1A1 (0.45) | IMPDH2TDP1ALDH1A1TSHRMAPT | |
| SCHEMBL5199170 | 0.78 | TDP1 (0.43) | IMPDH2TDP1ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL5610695 | 0.76 | MEN1 (0.44) | IMPDH2ALDH1A1TSHRMAPTSMN1; SMN2 | |
| SCHEMBL6275780 | 0.75 | TSHR (0.50) | TDP1ALDH1A1TSHRMAPTSMN1; SMN2 | |
| SCHEMBL6176152 | 0.74 | TDP1 (0.60) | TDP1ALDH1A1TSHRMAPTSMN1; SMN2 | |
| SCHEMBL4667892 | 0.74 | ALDH1A1 (0.49) | ALDH1A1MAPTSMN1; SMN2KDM4ELMNA | |
| SCHEMBL16094926 | 0.74 | ALDH1A1 (0.46) | ALDH1A1MAPTSMN1; SMN2CYP3A4KDM4E | |
| SCHEMBL11983744 | 0.74 | ALDH1A1 (0.52) | TDP1ALDH1A1TSHRMAPTSMN1; SMN2 | |
| SCHEMBL28047042 | 0.72 | TDP1 (0.47) | TDP1ALDH1A1TSHRMAPTSMN1; SMN2 | |
| SCHEMBL6237101 | 0.72 | TSHR (0.49) | TDP1ALDH1A1TSHRMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3668496-A1 | AHR INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2020-06-24 | — | — | EP | disclosed |
| WO-2019036657-A1 | AHR INHIBITORS AND USES THEREOF | KYN THERAPEUTICS (US) | 2019-02-21 | — | — | WO | disclosed |