Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | GPR35 | Q9HC97 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.36 |
| ▸ | ABAT | P80404 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.35 |
| ▸ | SNCA | P37840 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20746013 | 0.78 | IMPDH2 (0.47) | TDP1TSHRSMN1; SMN2KMT2ACYP3A4 | |
| SCHEMBL6176152 | 0.77 | TDP1 (0.60) | TDP1GPR35TSHRSMN1; SMN2ERN1 | |
| SCHEMBL2148842 | 0.77 | GPR35 (0.60) | TDP1GPR35TSHRSMN1; SMN2ERN1 | |
| SCHEMBL5200338 | 0.75 | TYR (0.49) | TSHRKMT2AALDH1A1 | |
| SCHEMBL17368428 | 0.75 | ERN1 (0.59) | TDP1GPR35TSHRSMN1; SMN2ERN1 | |
| SCHEMBL1559790 | 0.73 | GPR35 (0.41) | GPR35ERN1XDHALDH5A1ABAT | |
| SCHEMBL2327509 | 0.73 | BACE1 (0.46) | TSHRERN1ALDH1A1XDHALDH5A1 | |
| SCHEMBL4387980 | 0.73 | TSHR (0.56) | TDP1GPR35TSHRKMT2ACYP3A4 | |
| SCHEMBL406455 | 0.73 | TSHR (0.56) | GPR35TSHRKMT2ACYP3A4ALDH1A1 | |
| SCHEMBL31239069 | 0.73 | TSHR (0.56) | TDP1GPR35TSHRKMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3668496-A1 | AHR INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2020-06-24 | — | — | EP | disclosed |
| WO-2019036657-A1 | AHR INHIBITORS AND USES THEREOF | KYN THERAPEUTICS (US) | 2019-02-21 | — | — | WO | disclosed |
| EP-1817301-A1 | POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006057870-A1 | POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2006-06-01 | — | — | WO | disclosed |