Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | LDHA | P00338 | 1/20 | 0.34 |
| ▸ | LDHB | P07195 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20746527 | 1.00 | LMNA (0.38) | LMNAMAPTKMT2ANPSR1HDAC1 | |
| SCHEMBL20746572 | 0.87 | EGFR (0.41) | LMNAMAPTKMT2ANPSR1HDAC1 | |
| SCHEMBL20746573 | 0.87 | EGFR (0.41) | LMNAMAPTKMT2ANPSR1HDAC1 | |
| SCHEMBL20746236 | 0.86 | GAA (0.52) | LMNAMAPTKMT2ANPSR1HDAC1 | |
| SCHEMBL20746235 | 0.86 | GAA (0.52) | LMNAMAPTKMT2ANPSR1HDAC1 | |
| SCHEMBL20746448 | 0.84 | KMT2A (0.53) | LMNAMAPTKMT2ANPSR1HDAC1 | |
| SCHEMBL20746446 | 0.84 | KMT2A (0.53) | LMNAMAPTKMT2ANPSR1HDAC1 | |
| SCHEMBL20746571 | 0.82 | NPC1 (0.50) | LMNAMAPTKMT2ANPSR1NPC1 | |
| SCHEMBL20746570 | 0.82 | NPC1 (0.50) | LMNAMAPTKMT2ANPSR1NPC1 | |
| SCHEMBL20746319 | 0.81 | TBXAS1 (0.40) | LMNAMAPTKMT2AMAOBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200385374-A1 | IMIDAZOLE-BASED ANTICANCER AGENTS AND DERIVATIVES THEREOF, AND METHODS OF MAKING AND USING SAME | THE UNIVERSITY OF TOLEDO (US) | 2020-12-10 | — | — | US | claimed |
| US-20200385374-A1 | IMIDAZOLE-BASED ANTICANCER AGENTS AND DERIVATIVES THEREOF, AND METHODS OF MAKING AND USING SAME | THE UNIVERSITY OF TOLEDO (US) | 2020-12-10 | — | — | US | disclosed |
| WO-2019036607-A1 | IMIDAZOLE-BASED ANTICANCER AGENTS AND DERIVATIVES THEREOF, AND METHODS OF MAKING AND USING SAME | THE UNIVERSITY OF TOLEDO (US) | 2019-02-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200385374-A1 | IMIDAZOLE-BASED ANTICANCER AGENTS AND DERIVATIVES THEREOF, AND METHODS OF MAKING AND USING SAME | HDAC1, HDAC8, HDAC2 | LMNA 2343/4885MAPT 3302/4885KMT2A 70/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.